Barberis M C, Vago L, Cecchini G, Bramerio M, Banfi G, D'Amico M, Cannone M
Diagnostic Laboratories, E. Bernardelli Foundation, Paderno Dugnano, Milan, Italy.
Tumori. 1998 Jul-Aug;84(4):489-92. doi: 10.1177/030089169808400410.
The aim of this study was to compare the local immune response in two groups of patients with high-grade cervical intraepithelial squamous lesions (SIL): one with HIV infection and the other with HPV infection alone.
16 conization specimens (8 from HIV-infected and 8 from non-HIV-infected patients) of HPV-related, high-grade SIL were selected. The specimens from non-HIV patients were considered as controls. The total number of Langerhans cells, CD4 and CD8 cells present in 10 field areas (3.120 mm2) was recorded in each case. In HIV patients CD4 and CD8 peripheral counts were performed immediately before surgery.
The CD4/CD8 ratio never exceeded 0.71, whereas the lowest ratio in controls was 0.81: this difference was statistically significant (P = 0.0009). The mean number of Langerhans cells was markedly reduced in the high-grade SILs in the HIV patients in comparison with controls (P = 0.001). The number of CD4 cells and the CD4/CD8 ratio correlated with the peripheral CD4 count (P = 0.001 and 0.02).
In our study a marked local impairment of cervical immunoreactivity was observed, which may play a major role in the progression of these lesions in HIV-infected women.
本研究旨在比较两组高级别宫颈上皮内鳞状病变（SIL）患者的局部免疫反应：一组为HIV感染者，另一组为仅感染HPV者。
选取16例HPV相关高级别SIL的锥切标本（8例来自HIV感染患者，8例来自非HIV感染患者）。将非HIV患者的标本作为对照。记录每例患者10个视野区域（3.120平方毫米）内朗格汉斯细胞、CD4和CD8细胞的总数。对HIV患者在手术前立即进行外周血CD4和CD8计数。
HIV患者的CD4/CD8比值从未超过0.71，而对照组的最低比值为0.81：这种差异具有统计学意义（P = 0.0009）。与对照组相比，HIV患者高级别SIL中朗格汉斯细胞的平均数量明显减少（P = 0.001）。CD4细胞数量和CD4/CD8比值与外周血CD4计数相关（P = 0.001和0.02）。
在我们的研究中，观察到宫颈免疫反应存在明显的局部损害，这可能在HIV感染女性这些病变的进展中起主要作用。
