Mirsattari S M, Power C, Fine A, McGinn G S, Ludwick S, Canvin J M
Department of Internal Medicine, University of Manitoba Health Sciences Centre, Winnipeg, Canada.
Br J Rheumatol. 1998 Oct;37(10):1132-4. doi: 10.1093/rheumatology/37.10.1132.
The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with neuropsychiatric lupus (NP-SLE) is rare. We report a case of SIADH associated with the new onset of SLE in an 88-yr-old female. The unique features of this case include the extreme age of onset of SLE presenting with neuropsychiatric manifestations and positive antiribosomal P antibody titres. Both the NP manifestations of SLE and SIADH were highly correlated with the SLE disease activity. This case illustrates a novel presentation of NP-SLE with SIADH which may develop due to antibody-mediated hypothalamic dysfunction.
抗利尿激素分泌不当综合征（SIADH）与神经精神性狼疮（NP-SLE）相关的情况较为罕见。我们报告了一例88岁女性患者，其SIADH与新发系统性红斑狼疮（SLE）相关。该病例的独特之处包括SLE发病年龄极高，伴有神经精神症状，且抗核糖体P抗体滴度呈阳性。SLE的NP表现和SIADH均与SLE疾病活动度高度相关。该病例说明了NP-SLE合并SIADH的一种新表现形式，可能是由于抗体介导的下丘脑功能障碍所致。
