Subba Rao P V, Rajagopal D, Ganesh K A
Department of Biochemistry, Indian Institute of Science, Vittal Mallya Scientific Research Foundation, Bangalore.
Allergy. 1998;53(46 Suppl):44-7. doi: 10.1111/j.1398-9995.1998.tb04959.x.
The major crustacean allergen characterized from different species of shrimp is the muscle protein tropomyosin. Two shared epitopes corresponding to 47-63 and 150-158 of the deduced amino-acid sequence of the brown shrimp, M. ensis, were identified as IgE-binding B-cell epitopes. A 21-mer peptide spanning the amino-acid residues 261-281 was identified as a putative T-cell epitope capable of reducing ongoing tropomyosin-specific IgG and IgE responses in a mouse model. These observations suggest that peptide immunotherapy may also be effective in the treatment of food hypersensitivity.
从不同种类虾中鉴定出的主要甲壳类过敏原是肌肉蛋白原肌球蛋白。与褐虾（东方对虾）推导氨基酸序列的47 - 63和150 - 158相对应的两个共享表位被鉴定为IgE结合B细胞表位。一个跨越氨基酸残基261 - 281的21聚体肽被鉴定为一个假定的T细胞表位，它能够在小鼠模型中降低正在进行的原肌球蛋白特异性IgG和IgE反应。这些观察结果表明，肽免疫疗法在食物过敏治疗中可能也有效。
