Tohgi H, Abe T, Saheki M, Yamazaki K, Takahashi S
Department of Neurology, Iwate Medical University, Morioka, Japan.
Neurosci Lett. 1996 Mar 22;207(1):5-8. doi: 10.1016/0304-3940(96)12475-7.
In order to investigate the role of free radicals in the pathogenesis of sporadic amyotrophic lateral sclerosis (SALS), the concentrations of alpha-tocopherol (alpha-TOH) and its oxidized form alpha-tocopherol quinone (alpha-TQ) in the cerebrospinal fluid (CSF) of SALS patients were determined. The alpha-TOH level was 31% lower (P < 0.05) and the alpha-TQ level was 75% lower (P < 0.001) in SALS patients than in normal subjects. The results of the present study do not support the hypothesis that activated lipid peroxidation accelerates oxidation of alpha-TOH into alpha-TQ in SALS patients.
为了研究自由基在散发性肌萎缩侧索硬化症（SALS）发病机制中的作用，测定了SALS患者脑脊液（CSF）中α-生育酚（α-TOH）及其氧化形式α-生育酚醌（α-TQ）的浓度。与正常受试者相比，SALS患者的α-TOH水平降低了31%（P < 0.05），α-TQ水平降低了75%（P < 0.001）。本研究结果不支持活化的脂质过氧化加速SALS患者体内α-TOH氧化为α-TQ这一假说。
