Jiménez-Jiménez F J, de Bustos F, Molina J A, Benito-León J, Tallón-Barranco A, Gasalla T, Ortí-Pareja M, Guillamón F, Rubio J C, Arenas J, Enríquez-de-Salamanca R
Department of Neurology, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain.
J Neural Transm (Vienna). 1997;104(6-7):703-10. doi: 10.1007/BF01291887.
We compared CSF and serum levels, and the CST/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 44 apparently well-nourished patients with Alzheimer's disease (AD) and 37 matched controls. CSF and serum vitamin E levels were correlated, both in AD patients and in controls. The mean CSF and serum vitamin E levels were significantly lower in AD patients, and the CSF/serum ratio of AD patients did not differ significantly between the 2 study groups. CSF vitamin E levels did not correlate with age, age at onset, duration of the disease and score of the Minimental State Examination in the AD group. Weight and body mass index were significantly lower in AD patients than in controls. These results suggest that low CSF and serum vitamin E concentrations in AD patients could be related with a deficiency of dietary intake of vitamin E.
我们比较了44名营养状况良好的阿尔茨海默病（AD）患者和37名匹配对照者的脑脊液（CSF）和血清中通过高效液相色谱法（HPLC）测定的α-生育酚（维生素E）水平以及CST/血清比值。AD患者和对照者的脑脊液和血清维生素E水平均具有相关性。AD患者的脑脊液和血清维生素E平均水平显著较低，且两个研究组中AD患者的脑脊液/血清比值无显著差异。AD组中脑脊液维生素E水平与年龄、发病年龄、病程及简易精神状态检查表评分均无相关性。AD患者的体重和体重指数显著低于对照者。这些结果表明，AD患者脑脊液和血清维生素E浓度较低可能与维生素E饮食摄入不足有关。
