p50激活型和p58抑制型自然杀伤细胞受体与HLA-C的差异性结合
Differential binding to HLA-C of p50-activating and p58-inhibitory natural killer cell receptors.
作者信息
Valés-Gómez M, Reyburn H T, Erskine R A, Strominger J
机构信息
Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge MA 02138, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14326-31. doi: 10.1073/pnas.95.24.14326.
Abstract
Natural killer (NK) cell cytotoxicity is regulated in large part by the expression of NK cell receptors able to bind class I major histocompatibility complex glycoproteins. The receptors associated with recognition of HLA-C allospecificities are the two-domain Ig-like molecules, p50 and p58 proteins, with highly homologous extracellular domains but differing in that they have either an activating or inhibitory function, respectively, depending on the transmembrane domain and cytoplasmic tails that they possess. We have compared the binding to HLA-Cw7 of an inhibitory p58 molecule, NKAT2, the highly homologous activating p50 molecule, clone 49, and a second activating p50 molecule, clone 39, which has homologies to both NKAT1 and NKAT2. NKAT2 binds to HLA-Cw7 with very rapid association and dissociation rates. However, the p50 receptors bind only very weakly, if at all, to HLA-C. The molecular basis of this difference is analyzed, and the functional significance of these observations is discussed.
摘要
自然杀伤（NK）细胞的细胞毒性在很大程度上受能够结合I类主要组织相容性复合体糖蛋白的NK细胞受体表达的调节。与HLA - C同种异体特异性识别相关的受体是两结构域免疫球蛋白样分子，即p50和p58蛋白，它们具有高度同源的细胞外结构域，但不同之处在于，根据它们所具有的跨膜结构域和细胞质尾巴，它们分别具有激活或抑制功能。我们比较了抑制性p58分子NKAT2、高度同源的激活性p50分子克隆49以及与NKAT1和NKAT2均具有同源性的第二个激活性p50分子克隆39与HLA - Cw7的结合情况。NKAT2与HLA - Cw7结合的缔合和解离速率非常快。然而，p50受体与HLA - C的结合非常弱，甚至根本不结合。分析了这种差异的分子基础，并讨论了这些观察结果的功能意义。
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本文引用的文献
1
Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors.HLA - C配体与自然杀伤细胞抑制性受体相互作用的动力学
Immunity. 1998 Sep;9(3):337-44. doi: 10.1016/s1074-7613(00)80616-0.
2
HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer.与HLA-E结合的肽段影响抑制性和激活性CD94/NKG2受体的识别：对一种源自HLA-G的九聚体的优先反应。
Eur J Immunol. 1998 Sep;28(9):2854-63. doi: 10.1002/(SICI)1521-4141(199809)28:09<2854::AID-IMMU2854>3.0.CO;2-W.
3
4
NK cell receptors.自然杀伤细胞受体
Annu Rev Immunol. 1998;16:359-93. doi: 10.1146/annurev.immunol.16.1.359.
5
Nucleotide and amino acid sequence alignment for human killer cell inhibitory receptors (KIR), 1998.
Tissue Antigens. 1998 Apr;51(4 Pt 1):398-413. doi: 10.1111/j.1399-0039.1998.tb02981.x.
6
HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A.HLA - E是自然杀伤细胞抑制性受体CD94/NKG2A的主要配体。
Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5199-204. doi: 10.1073/pnas.95.9.5199.
7
Signaling through human killer cell activating receptors triggers tyrosine phosphorylation of an associated protein complex.通过人类杀伤细胞激活受体发出的信号会触发相关蛋白复合物的酪氨酸磷酸化。
Eur J Immunol. 1998 Feb;28(2):599-609. doi: 10.1002/(SICI)1521-4141(199802)28:02<599::AID-IMMU599>3.0.CO;2-F.
8
Natural killer activating receptors trigger interferon gamma secretion from T cells and natural killer cells.自然杀伤细胞激活受体触发T细胞和自然杀伤细胞分泌γ干扰素。
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9
Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.带有基于酪氨酸的激活基序的免疫受体DAP12参与激活自然杀伤细胞。
Nature. 1998 Feb 12;391(6668):703-7. doi: 10.1038/35642.
10
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Nature. 1998 Feb 19;391(6669):795-9. doi: 10.1038/35869.
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