• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Organization of immunoglobulin genes.

作者信息

Tonegawa S, Brack C, Hozumi N, Pirrotta V

出版信息

Cold Spring Harb Symp Quant Biol. 1978;42 Pt 2:921-31. doi: 10.1101/sqb.1978.042.01.094.

DOI:10.1101/sqb.1978.042.01.094
PMID:98276
Abstract

The nucleotide-sequence determination of a cloned, embryonic Vlambda gene directly demonstrated that V genes are separate from a corresponding C gene in embryonic cells. Analysis by restriction enzymes of total cellular DNA from various sources strongly suggested that the two separate immunoglobulin genes become continuous during differentiation of B lymphocytes. There seems to be a strict correlation between the joining event and activation of the joined genes. Cloning of more immunoglobulin genes from embryo and plasma cells will not only provide direct demonstration of such a gene-joining event but also help in the elucidation of a possible relationship of the event to gene activation mechanisms.

摘要

相似文献

1
Organization of immunoglobulin genes.
Cold Spring Harb Symp Quant Biol. 1978;42 Pt 2:921-31. doi: 10.1101/sqb.1978.042.01.094.
2
A complete immunoglobulin gene is created by somatic recombination.一个完整的免疫球蛋白基因是通过体细胞重组产生的。
Cell. 1978 Sep;15(1):1-14. doi: 10.1016/0092-8674(78)90078-8.
3
Organization of four mouse lambda light chain immunoglobulin genes.四个小鼠λ轻链免疫球蛋白基因的组织
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3765-9. doi: 10.1073/pnas.78.6.3765.
4
Immunoglobulin genes.免疫球蛋白基因
Mol Immunol. 1980 Nov;17(11):1423-35. doi: 10.1016/0161-5890(80)90012-7.
5
[Genetics of immunoglobulins].[免疫球蛋白的遗传学]
Zh Mikrobiol Epidemiol Immunobiol. 1980 May(5):34-40.
6
Antibody diversity.抗体多样性
Science. 1978 Oct 6;202(4363):11-7. doi: 10.1126/science.99815.
7
Restricted association of V and J-C gene segments for mouse lambda chains.小鼠λ链V和J-C基因片段的限制性组合
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2484-8. doi: 10.1073/pnas.81.8.2484.
8
The arrangement and rearrangement of antibody genes.抗体基因的排列与重排。
Nature. 1978;276(5690):790-5. doi: 10.1038/276790a0.
9
Immunoglobulin gene 'remnant' DNA--implications for antibody gene recombination.免疫球蛋白基因“残留”DNA——对抗体基因重组的影响
Nucleic Acids Res. 1984 May 25;12(10):4229-46. doi: 10.1093/nar/12.10.4229.
10
Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.免疫球蛋白λI和λIII恒定区基因的物理连锁。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3829-33. doi: 10.1073/pnas.78.6.3829.

引用本文的文献

1
The discovery of agammaglobulinaemia in 1952.1952年无丙种球蛋白血症的发现。
Eur J Pediatr. 2003 May;162(5):289-304. doi: 10.1007/s00431-003-1153-7. Epub 2003 Mar 1.
2
Chemical carcinogenesis -- the price for DNA - repair?化学致癌作用——DNA修复的代价？
Naturwissenschaften. 1982 Mar;69(3):107-13. doi: 10.1007/BF00376714.
3
Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer.利用寡聚脱氧核苷酸引物分离人组织相容性抗原HLA - B的cDNA克隆并测定其部分核苷酸序列。
Proc Natl Acad Sci U S A. 1981 Jan;78(1):616-20. doi: 10.1073/pnas.78.1.616.
4
Detection and location of three simple sequence DNAs in polytene chromosomes from virilis group species of Drosophila.果蝇属果蝇种的多线染色体中三种简单序列DNA的检测与定位
Chromosoma. 1979 Aug;73(3):327-55. doi: 10.1007/BF00288696.