Kaioumova D F, Khabutdinova L Kh
Clinical Diagnostic Laboratory, Republican Clinical Hospital, Russia, Ufa.
Chemosphere. 1998 Oct-Nov;37(9-12):1755-9. doi: 10.1016/s0045-6535(98)00240-9.
In the present study, we investigated the effect of dioxin-containing products on the cytogenetic characteristics of peripheral blood lymphocytes of herbicide plant workers in Ufa. We found that the mean incidence of cells with chromosomal abberations (CHA) was two fold higher in the herbicide plant workers than the mean incidence level of controls groups consisting of people with no professional contact to herbicides or hospital stuff working in the close vicinity of the herbicide plant in Ufa (for both cases: p < 0.05). Moreover, the mean CHA cell incidence in the controls groups was also two times higher than the average level of spontaneous abberations in humans. The chemical herbicides 2,4,5-trichlorphenol (2,4,5-T) and 2,4-dichlorophenoxiacetic acid (2,4-D) appeared to affect various cellular cycle phases. Chromosomal type abberations occurred in the G0 stage of cellular cycle and chromatic type aberrations in the G2 stage. In the S stage, the aberrations of both types were observed. Our results indicate that the herbicides 2,4,5-T and 2,4-D have mutagenic effects in humans.
在本研究中，我们调查了含二恶英产品对乌法市除草剂厂工人外周血淋巴细胞细胞遗传学特征的影响。我们发现，除草剂厂工人中染色体畸变（CHA）细胞的平均发生率比由无除草剂职业接触者或乌法市除草剂厂附近工作的医院工作人员组成的对照组的平均发生率水平高出两倍（两种情况：p < 0.05）。此外，对照组中CHA细胞的平均发生率也比人类自发畸变的平均水平高出两倍。化学除草剂2,4,5-三氯苯酚（2,4,5-T）和2,4-二氯苯氧乙酸（2,4-D）似乎会影响细胞周期的各个阶段。染色体型畸变发生在细胞周期的G0期，染色质型畸变发生在G2期。在S期，两种类型的畸变均有观察到。我们的结果表明，除草剂2,4,5-T和2,4-D对人类有致突变作用。
