Weiss D J, Evanson O A, MacLeay J, Brown D R
Department of Veterinary PathoBiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
Am J Vet Res. 1998 Nov;59(11):1431-4.
To determine whether mucosal permeability is altered during the prodromal stages of alimentary laminitis.
15 healthy adult ponies.
intestinal permeability was evaluated for control ponies (n = 5) and for ponies 4 to 12 (n = 5) and 20 to 28 (n = 5) hours after administration of carbohydrate overload. Mucosal permeability was determined by measuring the percentage of orally administered technetium Tc99m diethylenetriaminopentaacetate (99mTc-DTPA) excreted in urine during an 8-hour period, then measuring blood radioactivity at hourly intervals. Plasma endotoxin-like activity was measured by use of a chromogenic Limulus amebocyte assay.
Urinary excretion of 99mTc-DTPA was 2.45% of administered dose for control ponies, and was 16.67% of administered dose 4 to 12 hours and 3.57% of administered dose 20 to 28 hours after administration of carbohydrate.
A marked but transient increase in intestinal permeability was observed early in the prodromal stages of alimentary laminitis.
Absorption of substances from the intestine may be an initiating event in alimentary laminitis.
确定在消化性马肢皮炎前驱期黏膜通透性是否改变。
15匹健康成年矮种马。
对对照组矮种马（n = 5）以及给予碳水化合物过量后4至12小时（n = 5）和20至28小时（n = 5）的矮种马进行肠道通透性评估。通过测量8小时内口服的锝Tc99m二乙三胺五乙酸（99mTc - DTPA）经尿液排泄的百分比来测定黏膜通透性，然后每隔一小时测量血液放射性。使用显色鲎试剂法测量血浆内毒素样活性。
对照组矮种马99mTc - DTPA的尿液排泄量为给药剂量的2.45%，给予碳水化合物后4至12小时为给药剂量的16.67%，20至28小时为给药剂量的3.57%。
在消化性马肢皮炎前驱期早期观察到肠道通透性显著但短暂增加。
肠道物质吸收可能是消化性马肢皮炎的起始事件。
