Verallo-Rowell V M, Verallo V, Graupe K, Lopez-Villafuerte L, Garcia-Lopez M
Department of Dermatology, Makati Medical Center, Manila, Philippines.
Acta Derm Venereol Suppl (Stockh). 1989;143:58-61. doi: 10.2340/000155551435861.
Melasma is a macular hypermelanosis of the sun-exposed areas of the face and neck. The clinical efficacy of azelaic acid (20%) and hydroquinone creams (2%) in the treatment of this benign pigmentary disorder was compared in a randomized, double-blind study with 155 patients of Indo-Malay-Hispanic origin. The creams were applied twice daily. A broad spectrum sunscreen was used concomitantly. Over a period of 24 weeks, 73% of the azelaic acid patients, compared with 19% of the hydroquinone patients, had good to excellent overall results, as measured by the reduction of melasma pigmentary intensity and lesion size. Transient mild to moderate irritant reactions were initially seen with both test drugs.
黄褐斑是面部和颈部暴露于阳光下区域的斑片状色素沉着过度。在一项针对155名印度 - 马来 - 西班牙裔患者的随机双盲研究中，比较了壬二酸（20%）乳膏和氢醌乳膏（2%）治疗这种良性色素沉着疾病的临床疗效。两种乳膏均每日涂抹两次。同时使用广谱防晒霜。在24周的时间里，通过黄褐斑色素沉着强度和皮损大小的降低来衡量，73%使用壬二酸的患者取得了良好至极佳的总体效果，而使用氢醌的患者这一比例为19%。两种受试药物最初均出现了短暂的轻度至中度刺激反应。
