Chen B H, Giudice L C
Department of Gynecology and Obstetrics/Division of Gynecology, Stanford University, California, USA.
West J Med. 1998 Nov;169(5):280-4.
Abnormal uterine bleeding is a common, debilitating condition. Dysfunctional uterine bleeding (DUB) is the diagnosis given to women with abnormal uterine bleeding in whom no clear etiology can be identified. DUB has been observed in both ovulatory and anovulatory cycles. Medical treatments include nonsteroidal anti-inflammatory drugs, oral contraceptive pills, progestins, danazol (a synthetic androgen), GnRH agonists, and antifibrinolytic drugs. The drawback to medical therapy, in addition to side effects, is that the benefit lasts only while the patient takes the medication. Surgical options have concentrated mainly on endometrial ablation and hysterectomy, and it is unclear whether one is superior to the other in terms of long-term outcome and patient satisfaction. Newer and less invasive ablation techniques, such as thermal balloon ablation, offer more treatment alternatives.
异常子宫出血是一种常见的、使人虚弱的病症。功能失调性子宫出血（DUB）是指对异常子宫出血且无法明确病因的女性所做出的诊断。在有排卵和无排卵周期中均观察到了DUB。药物治疗包括非甾体类抗炎药、口服避孕药、孕激素、达那唑（一种合成雄激素）、促性腺激素释放激素（GnRH）激动剂和抗纤维蛋白溶解药物。药物治疗的缺点，除了副作用外，还在于只有在患者服药期间才有疗效。手术选择主要集中在子宫内膜消融术和子宫切除术，而就长期疗效和患者满意度而言，尚不清楚哪种手术更具优势。更新的、侵入性较小的消融技术，如热球囊消融术，提供了更多的治疗选择。
