急性运动对血浆同型半胱氨酸的影响。

Effect of acute exercise on plasma homocysteine.

作者信息

Wright M, Francis K, Cornwell P

机构信息

Department of Rehabilitation Sciences, University of Alabama at Birmingham 39294, USA.

出版信息

J Sports Med Phys Fitness. 1998 Sep;38(3):262-5.

PMID:9830836

Abstract

BACKGROUND

The aim this work was to study the effects of acute exercise on plasma homocysteine level.

METHODS

Twenty healthy, physically active males aged 24-39 (X = 29) ran on treadmill at an intensity of 70% of their maximal heart for 30 minutes. Blood was taken before, immediately following and 30 minutes following the exercise bout.

RESULTS

There was no statistically significant relationship between pre-exercise plasma homocysteine levels and VO2 max (r = -0.05). Plasma homocysteine significantly increased 11.5% from the pre-exercise to 11.6 +/- 3.3 mumol.L-1 immediate post exercise levels. Thirty minutes postexercise plasma homocysteine was still elevated from pre-exercise levels, however the mean of 11.2 +/- 2.9 mumol.L-1 was not statistically different from pre-exercise values. The increase in homocysteine that occurred with 30 minutes of exercise is thought to be the result of hemoconcentration as indicated by changes in plasma albumin. Plasma albumin likewise paralleled the changes observed for homocysteine. Mean pre-exercise plasma albumin values were 42.9 +/- 2.9 g.L-1. Plasma albumin significantly increased 6.9% to 45.8 +/- 2.4 g.L-1 immediately post-exercise. Thirty minutes post exercise plasma albumin was still elevated from pre-exercise levels at 44.8 +/- 5.4 g.L-1. When the homocysteine plasma levels were adjusted for changes in plasma albumin, there was no statistical difference between any of the time points.

CONCLUSIONS

It was concluded that acute exercise does not have any effect on plasma homocysteine in young healthy men aged 24-39.

摘要

背景

本研究旨在探讨急性运动对血浆同型半胱氨酸水平的影响。

方法

选取20名年龄在24 - 39岁（平均年龄29岁）的健康、有体育锻炼习惯的男性，在跑步机上以最大心率的70%强度跑步30分钟。在运动前、运动结束后即刻以及运动结束后30分钟采集血液样本。

结果

运动前血浆同型半胱氨酸水平与最大摄氧量之间无统计学显著相关性（r = -0.05）。运动后即刻血浆同型半胱氨酸水平较运动前显著升高11.5%，达到11.6 ± 3.3 μmol/L。运动后30分钟血浆同型半胱氨酸水平仍高于运动前，但平均水平为11.2 ± 2.9 μmol/L，与运动前值无统计学差异。运动30分钟后同型半胱氨酸的升高被认为是血液浓缩所致，这可通过血浆白蛋白的变化得到证实。血浆白蛋白的变化与同型半胱氨酸相似。运动前血浆白蛋白平均水平为42.9 ± 2.9 g/L。运动后即刻血浆白蛋白显著升高6.9%，达到45.8 ± 2.4 g/L。运动后30分钟血浆白蛋白水平仍高于运动前，为44.8 ± 5.4 g/L。当对血浆同型半胱氨酸水平进行血浆白蛋白变化的校正后，各时间点之间无统计学差异。