Fehn M, Lohmann F, Lüdecke D K, Rudorff K H, Saeger W
Institute of Pathology of the Marienkrankenhaus, Hamburg, Germany.
Exp Clin Endocrinol Diabetes. 1998;106(5):425-30. doi: 10.1055/s-0029-1212010.
A patient with a ganglioglioma of the neurohypophysis developed the syndrome of inappropriate antidiuretic hormone secretion (SIADH). We present the case and describe its microscopic and ultrastructural features. Malignant neoplasms were thought to be the main cause of ectopic production of vasopressin. Head trauma, infection, or drugs, however, can also induce hypersecretion of vasopressin. Mechanical compression of the pituitary stalk can lead to an excessive antidiuretic hormone (ADH) release by affecting the inhibitory system. Primary neuroendocrine tumors of the hypothalamic-neurohypophyseal system are extremely rare. We demonstrate the presence of vasopressin in the tumor cells by immunocytochemistry. This represents the first case of SIADH caused by a tumor of the neurohypophysis.
一名患有神经垂体节细胞胶质瘤的患者出现了抗利尿激素分泌不当综合征（SIADH）。我们报告该病例并描述其微观和超微结构特征。恶性肿瘤被认为是血管加压素异位产生的主要原因。然而，头部创伤、感染或药物也可诱导血管加压素分泌过多。垂体柄的机械性压迫可通过影响抑制系统导致抗利尿激素（ADH）过度释放。下丘脑 - 神经垂体系统的原发性神经内分泌肿瘤极为罕见。我们通过免疫细胞化学证实肿瘤细胞中存在血管加压素。这是首例由神经垂体肿瘤引起的SIADH病例。
