Domoto H, Terahata S, Sato K, Tamai S
Department of Laboratory Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.
Pathol Int. 1998 Nov;48(11):907-11. doi: 10.1111/j.1440-1827.1998.tb03860.x.
Two cases of nodular hidradenoma of the breast with possibly different origins are reported. Case 1 is of a 58-year-old female with a breast mass in the left, outer lower-quadrant. A histogenetical origin in the skin adnexal glands was suspected due to its superficial location and immunohistochemical findings. Case 2 is of a 44-year-old male with a subareolar nodule and nipple discharge. Histological examination demonstrated that the tumor was located deep in the breast tissue, was surrounded by dilated mammary ducts and exhibited intraductal extensions, which are all features mimicking those of breast cancer. Immunohistochemical positivity against gross cystic disease fluid protein-15 was weakly identified and negativity for endoplasmic reticulum was observed. This case can be interpreted as arising in the mammary ducts. It is well known that various kinds of skin adnexal tumors arise in the breast tissue; however, nodular hidradenoma of the breast is still a rare benign neoplasm. Clinically, nodular hidradenoma of the breast tends to occur in the nipple or subareolar region of the female breast. It should be kept in mind that nodular hidradenoma may occur in mammary ducts and it should be included when differential diagnoses are made of subareolar breast tumors.
报告了两例可能起源不同的乳腺结节性汗腺瘤。病例1为一名58岁女性，左乳房外下象限有一肿块。因其浅表位置和免疫组化结果，怀疑其起源于皮肤附属器腺。病例2为一名44岁男性，乳晕下有一结节且有乳头溢液。组织学检查显示肿瘤位于乳腺组织深部，被扩张的乳腺导管包围，并表现出导管内延伸，这些特征均类似乳腺癌。大体囊肿病液体蛋白-15免疫组化呈弱阳性，内质网呈阴性。该病例可解释为起源于乳腺导管。众所周知，各种皮肤附属器肿瘤可发生于乳腺组织；然而，乳腺结节性汗腺瘤仍是一种罕见的良性肿瘤。临床上，乳腺结节性汗腺瘤倾向于发生在女性乳房的乳头或乳晕下区域。应牢记结节性汗腺瘤可能发生于乳腺导管，在对乳晕下乳腺肿瘤进行鉴别诊断时应将其纳入考虑。
