高剂量赖诺普利-硝酸异山梨酯对严重二尖瓣反流和心力衰竭重塑的影响。
Effects of high-dose lisinopril-isosorbide dinitrate on severe mitral regurgitation and heart failure remodeling.
作者信息
Levine A B, Muller C, Levine T B
机构信息
Michigan Institute for Heart Failure & Transplant Care, Farmington Hills 48336, USA.
出版信息
Am J Cardiol. 1998 Nov 15;82(10):1299-301, A10. doi: 10.1016/s0002-9149(98)00623-7.
In long-term, 1-year follow-up, uptitration of angiotensin-converting enzyme inhibitor and nitrate therapy over established doses can further improve severe functional mitral regurgitation in patients with dilated cardiomyopathy due to a reversal of heart failure-related left ventricular remodeling. With marked left ventricular enlargement, >6.8 cm end-diastolic diameter, heart failure remodeling may be irreversible and resistant to further medical intervention.
在为期1年的长期随访中，对于已服用既定剂量药物的患者，增加血管紧张素转换酶抑制剂和硝酸盐类药物的剂量可进一步改善扩张型心肌病患者的严重功能性二尖瓣反流，这是由于与心力衰竭相关的左心室重构得到了逆转。当左心室明显增大，舒张末期直径>6.8厘米时，心力衰竭性重构可能是不可逆的，并且对进一步的药物干预有抵抗性。
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