Kitagishi K, Shintani H
Otsuka Electronics Co., Hirakata, Osaka, Japan.
J Chromatogr B Biomed Sci Appl. 1998 Oct 9;717(1-2):327-39. doi: 10.1016/s0378-4347(98)00290-4.
Capillary electrophoresis (CE) is one of the suitable separation techniques used to analyze drugs or metabolites in complicated sample matrices such as plasma, serum and urine. It sometimes requires only a simple process of sample pretreatment, deproteinization, dilution or extraction for biological fluids, otherwise no pretreatment is necessary. Various metabolic disorders concerning the compounds which possess carboxyl groups such as organic acids have been monitored by CE. Drug metabolism in the body can be monitored by the same technique. Recent publications suggest the feasibility of an automated system for diagnosis based on CE technique.
毛细管电泳（CE）是用于分析复杂样品基质（如血浆、血清和尿液）中药物或代谢物的合适分离技术之一。对于生物流体，它有时仅需要简单的样品预处理过程，如脱蛋白、稀释或提取，否则无需预处理。通过CE已经监测了各种与具有羧基的化合物（如有机酸）相关的代谢紊乱。体内的药物代谢也可以通过相同技术进行监测。最近的出版物表明了基于CE技术的自动化诊断系统的可行性。
