• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Isochore evolution in mammals: a human-like ancestral structure.

作者信息

Galtier N, Mouchiroud D

机构信息

Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5558, Biométrie, Génétique et Biologie des Populations, Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France.

出版信息

Genetics. 1998 Dec;150(4):1577-84. doi: 10.1093/genetics/150.4.1577.

DOI:10.1093/genetics/150.4.1577
PMID:9832533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1460440/
Abstract

Codon usage in mammals is mainly determined by the spatial arrangement of genomic G + C-content, i.e., the isochore structure. Ancestral G + C-content at third codon positions of 27 nuclear protein-coding genes of eutherian mammals was estimated by maximum-likelihood analysis on the basis of a nonhomogeneous DNA substitution model, accounting for variable base compositions among present-day sequences. Data consistently supported a human-like ancestral pattern, i.e., highly variable G + C-content among genes. The mouse genomic structure-more narrow G + C-content distribution-would be a derived state. The circumstances of isochore evolution are discussed with respect to this result. A possible relationship between G + C-content homogenization in murid genomes and high mutation rate is proposed, consistent with the negative selection hypothesis for isochore maintenance in mammals.

摘要

相似文献

1
Isochore evolution in mammals: a human-like ancestral structure.
Genetics. 1998 Dec;150(4):1577-84. doi: 10.1093/genetics/150.4.1577.
2
Evolution of isochores in rodents.
Mol Biol Evol. 1997 Aug;14(8):823-8. doi: 10.1093/oxfordjournals.molbev.a025823.
3
A new framework for studying the isochore evolution: estimation of the equilibrium GC content based on the temporal mutation rate model.一种新的研究同调进化的框架：基于时变突变率模型估计平衡 GC 含量。
Genome Biol Evol. 2010;2:558-71. doi: 10.1093/gbe/evq041. Epub 2010 Jul 8.
4
Patterns of vertebrate isochore evolution revealed by comparison of expressed mammalian, avian, and crocodilian genes.通过比较表达的哺乳动物、鸟类和鳄鱼基因揭示的脊椎动物等密度区进化模式。
J Mol Evol. 2007 Sep;65(3):259-66. doi: 10.1007/s00239-007-9003-2. Epub 2007 Aug 3.
5
The guanine and cytosine content of genomic DNA and bacterial evolution.基因组DNA的鸟嘌呤和胞嘧啶含量与细菌进化
Proc Natl Acad Sci U S A. 1987 Jan;84(1):166-9. doi: 10.1073/pnas.84.1.166.
6
The compositional evolution of the murid genome.鼠科动物基因组的组成演变。
J Mol Evol. 2002 Aug;55(2):197-201. doi: 10.1007/s00239-002-2316-2.
7
A comparative study and a phylogenetic exploration of the compositional architectures of mammalian nuclear genomes.哺乳动物核基因组组成结构的比较研究与系统发育探索。
PLoS Comput Biol. 2014 Nov 6;10(11):e1003925. doi: 10.1371/journal.pcbi.1003925. eCollection 2014 Nov.
8
Biased gene conversion and GC-content evolution in the coding sequences of reptiles and vertebrates.爬行动物和脊椎动物编码序列中的偏向基因转换与GC含量进化。
Genome Biol Evol. 2014 Dec 19;7(1):240-50. doi: 10.1093/gbe/evu277.
9
The decline of isochores in mammals: an assessment of the GC content variation along the mammalian phylogeny.哺乳动物中同线区的衰退：对沿哺乳动物系统发育的GC含量变化的评估。
J Mol Evol. 2004 Jun;58(6):653-60. doi: 10.1007/s00239-004-2587-x.
10
A new perspective on isochore evolution.等容线进化的新视角。
Gene. 2006 Dec 30;385:71-4. doi: 10.1016/j.gene.2006.04.030. Epub 2006 Aug 5.

引用本文的文献

1
Circular RNA repertoires are associated with evolutionarily young transposable elements.环状 RNA 谱与进化上年轻的转座元件相关。
Elife. 2021 Sep 20;10:e67991. doi: 10.7554/eLife.67991.
2
Evolutionary Forces and Codon Bias in Different Flavors of Intrinsic Disorder in the Human Proteome.人类蛋白质组中不同类型固有无序区的进化力量和密码子偏好性。
J Mol Evol. 2020 Mar;88(2):164-178. doi: 10.1007/s00239-019-09921-4. Epub 2019 Dec 10.
3
Marsupial chromosome DNA content and genome size assessed from flow karyotypes: invariable low autosomal GC content.从流式核型分析评估有袋类动物染色体DNA含量和基因组大小：常染色体GC含量始终较低。
R Soc Open Sci. 2018 Aug 29;5(8):171539. doi: 10.1098/rsos.171539. eCollection 2018 Aug.
4
The bimodal distribution of genic GC content is ancestral to monocot species.基因GC含量的双峰分布是单子叶植物物种的祖先特征。
Genome Biol Evol. 2014 Dec 19;7(1):336-48. doi: 10.1093/gbe/evu278.
5
A comparative study and a phylogenetic exploration of the compositional architectures of mammalian nuclear genomes.哺乳动物核基因组组成结构的比较研究与系统发育探索。
PLoS Comput Biol. 2014 Nov 6;10(11):e1003925. doi: 10.1371/journal.pcbi.1003925. eCollection 2014 Nov.
6
Contrasting GC-content dynamics across 33 mammalian genomes: relationship with life-history traits and chromosome sizes.比较 33 种哺乳动物基因组中的 GC 含量动态：与生活史特征和染色体大小的关系。
Genome Res. 2010 Aug;20(8):1001-9. doi: 10.1101/gr.104372.109. Epub 2010 Jun 7.
7
Analysis of fine-scale mammalian evolutionary breakpoints provides new insight into their relation to genome organisation.对精细尺度哺乳动物进化断点的分析为其与基因组组织的关系提供了新的见解。
BMC Genomics. 2009 Jul 24;10:335. doi: 10.1186/1471-2164-10-335.
8
Characteristics of human and mouse orthologous protein-coding nucleotide sequences with large g+c content variations.具有大 GC 含量变化的人类和小鼠直系同源蛋白编码核苷酸序列的特征。
Curr Genomics. 2007 Nov;8(7):445-52. doi: 10.2174/138920207783591708.
9
Patterns of vertebrate isochore evolution revealed by comparison of expressed mammalian, avian, and crocodilian genes.通过比较表达的哺乳动物、鸟类和鳄鱼基因揭示的脊椎动物等密度区进化模式。
J Mol Evol. 2007 Sep;65(3):259-66. doi: 10.1007/s00239-007-9003-2. Epub 2007 Aug 3.
10
Hotspots of mutation and breakage in dog and human chromosomes.狗和人类染色体中的突变与断裂热点
Genome Res. 2005 Dec;15(12):1787-97. doi: 10.1101/gr.3896805.

本文引用的文献

1
Inferring pattern and process: maximum-likelihood implementation of a nonhomogeneous model of DNA sequence evolution for phylogenetic analysis.推断模式与过程：用于系统发育分析的DNA序列进化非齐次模型的最大似然实现。
Mol Biol Evol. 1998 Jul;15(7):871-9. doi: 10.1093/oxfordjournals.molbev.a025991.
2
Molecular phylogeny of rodents, with special emphasis on murids: evidence from nuclear gene LCAT.啮齿动物的分子系统发育，特别强调鼠科动物：来自核基因卵磷脂胆固醇酰基转移酶的证据。
Mol Phylogenet Evol. 1997 Dec;8(3):423-34. doi: 10.1006/mpev.1997.0424.
3
Compositional mapping of mouse chromosomes and identification of the gene-rich regions.小鼠染色体的组成图谱绘制及基因富集区域的鉴定。
Chromosome Res. 1997 Aug;5(5):293-300. doi: 10.1023/B:CHRO.0000038759.09018.a7.
4
Evolution of isochores in rodents.
Mol Biol Evol. 1997 Aug;14(8):823-8. doi: 10.1093/oxfordjournals.molbev.a025823.
5
Phylogenetic position of guinea pigs revisited.豚鼠系统发育位置的重新审视。
Mol Biol Evol. 1997 Apr;14(4):461-4. doi: 10.1093/oxfordjournals.molbev.a025782.
6
The chromosomal distribution of CpG islands in the mouse: evidence for genome scrambling in the rodent lineage.小鼠中CpG岛的染色体分布：啮齿动物谱系中基因组重排的证据。
Genomics. 1997 Mar 15;40(3):454-61. doi: 10.1006/geno.1996.4598.
7
The complete mitochondrial genome of the wallaroo (Macropus robustus) and the phylogenetic relationship among Monotremata, Marsupialia, and Eutheria.大袋鼠（Macropus robustus）的完整线粒体基因组以及单孔目、有袋目和真兽亚纲之间的系统发育关系。
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1276-81. doi: 10.1073/pnas.94.4.1276.
8
SEAVIEW and PHYLO_WIN: two graphic tools for sequence alignment and molecular phylogeny.SEAVIEW和PHYLO_WIN：用于序列比对和分子系统发育的两种图形工具。
Comput Appl Biosci. 1996 Dec;12(6):543-8. doi: 10.1093/bioinformatics/12.6.543.
9
Human coding and noncoding DNA: compositional correlations.人类编码和非编码DNA：组成相关性。
Mol Phylogenet Evol. 1996 Feb;5(1):2-12. doi: 10.1006/mpev.1996.0002.
10
Rates of nucleotide substitution in primates and rodents and the generation-time effect hypothesis.灵长类动物和啮齿动物的核苷酸替代率与世代时间效应假说。
Mol Phylogenet Evol. 1996 Feb;5(1):182-7. doi: 10.1006/mpev.1996.0012.