基因组DNA的鸟嘌呤和胞嘧啶含量与细菌进化
The guanine and cytosine content of genomic DNA and bacterial evolution.
作者信息
Muto A, Osawa S
出版信息
Proc Natl Acad Sci U S A. 1987 Jan;84(1):166-9. doi: 10.1073/pnas.84.1.166.
Abstract
The genomic guanine and cytosine (G + C) content of eubacteria is related to their phylogeny. The G + C content of various parts of the genome (protein genes, stable RNA genes, and spacers) reveals a positive linear correlation with the G + C content of their genomic DNA. However, the plotted correlation slopes differ among various parts of the genome or among the first, second, and third positions of the codons depending on their functional importance. Facts suggest that biased mutation pressure, called A X T/G X C pressure, has affected whole DNA during evolution so as to determine the genomic G + C content in a given bacterium. The role of A X T/G X C pressure in diversification of bacterial DNA sequences and codon usage patterns is discussed in the perspective of the neutral theory of molecular evolution.
摘要
真细菌的基因组鸟嘌呤和胞嘧啶（G + C）含量与其系统发育有关。基因组各部分（蛋白质基因、稳定RNA基因和间隔区）的G + C含量与其基因组DNA的G + C含量呈正线性相关。然而，根据其功能重要性，绘制的相关斜率在基因组的不同部分之间或密码子的第一、第二和第三位之间有所不同。事实表明，在进化过程中，一种称为A X T/G X C压力的偏向性突变压力影响了整个DNA，从而决定了特定细菌的基因组G + C含量。从分子进化的中性理论角度讨论了A X T/G X C压力在细菌DNA序列多样化和密码子使用模式中的作用。
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