Resch K, Schilling C, Borchert B D, Klatzko M, Uden D
Emergency and Clinical Pharmacy Departments, Children's Hospitals and Clinics-Minneapolis, MN, USA.
Ann Emerg Med. 1998 Dec;32(6):693-7. doi: 10.1016/s0196-0644(98)70069-1.
To compare the adequacy and efficacy of anesthesia experienced with lidocaine-epinephrine-tetracaine (LET) solution versus LET gel during suturing of uncomplicated lacerations on the face or scalp in children.
Two hundred children with lacerations of the face and scalp requiring suturing were enrolled in this blinded, randomized controlled trial, in the emergency department of a university-affiliated children's hospital. After the application of anesthetic solution or gel, adequacy of anesthesia was determined before suturing. Efficacy of anesthesia during laceration repair was determined by the length of time after removal of the topical anesthetic to the first sign of discomfort that required additional anesthesia or until suture completion.
Adequacy of initial anesthesia was equivalent between LET solution and LET gel. There was a significant difference in efficacy of anesthesia between the LET formulations. There were more patients with complete anesthesia (85% versus 76%), fewer persons with partial anesthesia (5% versus 21%), and more persons with incomplete anesthesia (9% versus 3%) in the gel group.
LET gel is at least as effective as LET solution and possesses theoretical advantages for topical anesthesia during suturing of uncomplicated lacerations on the face and scalp in children.
比较利多卡因 - 肾上腺素 - 丁卡因(LET)溶液与LET凝胶在儿童面部或头皮单纯性裂伤缝合过程中麻醉的充分性和有效性。
在一所大学附属医院的急诊科,200名需要缝合面部和头皮裂伤的儿童被纳入这项双盲随机对照试验。在应用麻醉溶液或凝胶后,缝合前确定麻醉的充分性。通过去除局部麻醉剂后到出现需要额外麻醉的第一个不适迹象或直到缝合完成的时间来确定裂伤修复过程中麻醉的有效性。
LET溶液和LET凝胶初始麻醉的充分性相当。LET制剂之间麻醉效果存在显著差异。凝胶组完全麻醉的患者更多(85%对76%),部分麻醉的患者更少(5%对21%),不完全麻醉的患者更多(9%对3%)。
LET凝胶至少与LET溶液一样有效,并且在儿童面部和头皮单纯性裂伤缝合期间的局部麻醉方面具有理论优势。