来自 Hoslundia opposita 叶片的吡喃酮和呋喃酮取代的类黄酮。

Pyrone and unusually furanone-substituted flavones from the leaves of Hoslundia opposita.

机构信息

Chimie des Substances Naturelles, CNRS UMR 8076 BioCIS, Labex LERMIT, Faculté de Pharmacie, Université Paris-Sud, Châtenay-Malabry, France.

出版信息

Planta Med. 2012 Nov;78(16):1777-9. doi: 10.1055/s-0032-1315256. Epub 2012 Sep 4.

DOI:10.1055/s-0032-1315256

PMID:22948611

Abstract

Two new unusual 6-furanoflavones, hoslunfuranine (5) and 5-O-methylhoslunfuranine (6), were isolated from the leaves of Hoslundia opposita Vahl.. Four known methylpyranoflavonic analogues [hosloppin (1), hoslundin (2), 5-O-methylhoslundin (3), oppositin (4)], all specific of the species, were also obtained. Their structures were established on the basis of their spectroscopic data. In vitro cytotoxic, trypanocidal, and leishmanicidal activities of compounds 1 and 3 to 6 were evaluated. Compounds 4 and 6 exhibited leishmanicidal potential in the micromolar range.

摘要

从胡颓子属 Hoslundia opposita Vahl 的叶子中分离得到了两种新的 6-呋喃黄酮类化合物 hoslunfuranine（5）和 5-O-甲基 hoslunfuranine（6）。还获得了四种已知的甲基吡喃黄酮类似物[hosloppin（1），hoslundin（2），5-O-甲基 hoslundin（3），oppositin（4）]，它们都是该物种特有的。根据光谱数据确定了它们的结构。评估了化合物 1 和 3 至 6 对体外细胞毒性、杀锥虫和杀利什曼原虫的活性。化合物 4 和 6 在微摩尔范围内表现出杀利什曼原虫的潜力。