Collado IG, Hanson JR, Macias-Sanchez AJ, Mobbs D
Departamento de Quimica Organica, Facultad de Ciencias, Universidad de Cadiz, Apartado 40, 11510, Puerto Real, Cadiz, Spain, and The School of Chemistry, Physics and Environmental Science, University of Sussex, Brighton, Susse.
J Nat Prod. 1998 Nov;61(11):1348-51. doi: 10.1021/np9801054.
The metabolism of the fungistatic agent 2beta-methoxyclovan-9alpha-ol (2) by the fungus Botrytis cinerea has been investigated. Biotransformation of compound 2 yielded compounds 3-5, 7, and 9. The major metabolites of compound 2 each show much reduced biological activity when compared with the parent compound. Also studied were the effects of B. cinerea on the metabolism of the related compounds 2beta-methoxyclovan-9-one (3), 2beta-methoxyclovan-9beta-ol (4), and clovan-2,9-dione (6). Compounds 3, 4, 8, and 9 are described for the first time.
