A new bromopyrrole alkaloid and the optical resolution of the racemate from the marine sponge homaxinella sp.

作者信息

Umeyama A, Ito S, Yuasa E, Arihara S, Yamada T

机构信息

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770, Japan, and Osaka University of Pharmaceutical Sciences 4-20-1, Nasahara, Takatsuki, Osaka 569-1041, Japan.

出版信息

J Nat Prod. 1998 Nov;61(11):1433-4. doi: 10.1021/np980207u.

A new bromopyrrole alkaloid (1) along with (+/-)-2 and (+/-)-longamide (3) has been isolated from the Japanese marine sponge Homaxinella sp. The structures of the compounds were proposed on the basis of spectroscopic data. The optical resolution of (+/-)-2 by chiral HPLC was successful and afforded the two enantiomers, (+)-2 and (-)-2.