大肠杆菌对β-内酰胺类和氟喹诺酮类抗生素的联合耐受性源于hipA的过表达。
Joint tolerance to beta-lactam and fluoroquinolone antibiotics in Escherichia coli results from overexpression of hipA.
作者信息
Falla T J, Chopra I
机构信息
Department of Microbiology and Antimicrobial Research Centre, University of Leeds, Leeds LS2 9JT, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1998 Dec;42(12):3282-4. doi: 10.1128/AAC.42.12.3282.
Abstract
The basis of joint tolerance to beta-lactam and fluoroquinolone antibiotics in Escherichia coli mediated by hipA was examined. An antibiotic tolerance phenotype was produced by overexpression of hipA under conditions that did not affect the growth rate of the organism. Overexpressing hipA probably decreases the period in which bacteria are susceptible to the antibiotics by temporarily affecting some aspect of chromosome replication or cell division.
摘要
研究了由hipA介导的大肠杆菌对β-内酰胺类和氟喹诺酮类抗生素的联合耐受性基础。在不影响生物体生长速率的条件下，通过过表达hipA产生了抗生素耐受表型。过表达hipA可能通过暂时影响染色体复制或细胞分裂的某些方面来缩短细菌对抗生素敏感的时期。
相似文献
1
Joint tolerance to beta-lactam and fluoroquinolone antibiotics in Escherichia coli results from overexpression of hipA.大肠杆菌对β-内酰胺类和氟喹诺酮类抗生素的联合耐受性源于hipA的过表达。
Antimicrob Agents Chemother. 1998 Dec;42(12):3282-4. doi: 10.1128/AAC.42.12.3282.
2
Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones.多重抗生素耐药性（mar）位点可保护大肠杆菌免受氟喹诺酮类药物的快速杀菌作用。
Antimicrob Agents Chemother. 1996 May;40(5):1266-9. doi: 10.1128/AAC.40.5.1266.
3
HipA-triggered growth arrest and β-lactam tolerance in Escherichia coli are mediated by RelA-dependent ppGpp synthesis.HipA 触发的大肠杆菌生长停滞和β-内酰胺耐受是由依赖 RelA 的 ppGpp 合成介导的。
J Bacteriol. 2013 Jul;195(14):3173-82. doi: 10.1128/JB.02210-12. Epub 2013 May 10.
4
Kinase activity of overexpressed HipA is required for growth arrest and multidrug tolerance in Escherichia coli.大肠杆菌中生长停滞和多药耐受性需要过表达的HipA的激酶活性。
J Bacteriol. 2006 Dec;188(24):8360-7. doi: 10.1128/JB.01237-06. Epub 2006 Oct 13.
5
A survey of plasmid-mediated fluoroquinolone resistance genes from Escherichia coli isolates and their dissemination in Shandong, China.中国山东大肠杆菌分离株中质粒介导氟喹诺酮耐药基因的调查及其传播。
Foodborne Pathog Dis. 2010 Feb;7(2):207-15. doi: 10.1089/fpd.2009.0378.
6
Association of organic solvent tolerance and fluoroquinolone resistance in clinical isolates of Escherichia coli.
J Antimicrob Chemother. 1998 Jan;41(1):111-4. doi: 10.1093/jac/41.1.111.
7
[In vitro activity of fluoroquinolones and oral beta lactam antibiotics against clinical isolates of Escherichia coli].氟喹诺酮类和口服β-内酰胺类抗生素对大肠埃希菌临床分离株的体外活性
Rev Esp Quimioter. 1999 Mar;12(1):54-7.
8
pMEX01, a 70kb plasmid isolated from Escherichia coli that confers resistance to multiple β-lactam antibiotics.pMEX01是一种从大肠杆菌中分离出的70kb质粒，它赋予对多种β-内酰胺类抗生素的抗性。
Braz J Microbiol. 2018 Jul-Sep;49(3):569-574. doi: 10.1016/j.bjm.2017.11.002. Epub 2018 Feb 3.
9
Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648.替加环素不敏感性仅在耐氟喹诺酮的大肠埃希菌临床分离株中出现，包括主要的多重耐药谱系O25b:H4-ST131-H30R和O1-ST648。
Antimicrob Agents Chemother. 2017 Jan 24;61(2). doi: 10.1128/AAC.01654-16. Print 2017 Feb.
10
HipBA-promoter structures reveal the basis of heritable multidrug tolerance.HipBA 启动子结构揭示了遗传性多药耐受的基础。
Nature. 2015 Aug 6;524(7563):59-64. doi: 10.1038/nature14662. Epub 2015 Jul 29.
引用本文的文献
1
The plasmid-borne hipBA operon of Klebsiella michiganensis encodes a potent plasmid stabilization system.密歇根杆菌质粒携带的 hipBA 操纵子编码了一个强效的质粒稳定系统。
J Appl Microbiol. 2024 Oct 3;135(10). doi: 10.1093/jambio/lxae246.
2
Streptozotocin-Induced Hyperglycemia Is Associated with Unique Microbiome Metabolomic Signatures in Response to Ciprofloxacin Treatment.链脲佐菌素诱导的高血糖与环丙沙星治疗反应中独特的微生物组代谢组学特征相关。
Antibiotics (Basel). 2022 Apr 27;11(5):585. doi: 10.3390/antibiotics11050585.
3
Transcriptional repression in stochastic gene expression, patterning, and cell fate specification.随机基因表达、模式形成和细胞命运特化中的转录抑制。
Dev Biol. 2022 Jan;481:129-138. doi: 10.1016/j.ydbio.2021.10.002. Epub 2021 Oct 21.
4
Studies of Persister Cells.持久性细胞研究。
Microbiol Mol Biol Rev. 2020 Nov 11;84(4). doi: 10.1128/MMBR.00070-20. Print 2020 Nov 18.
5
Non-walled spherical is an important type of persister upon -lactam antibiotic treatment.无壁球形细胞是耐β-内酰胺类抗生素治疗的重要持久性细胞类型。
Emerg Microbes Infect. 2020 Dec;9(1):1149-1159. doi: 10.1080/22221751.2020.1770630.
6
Molecular Characterization of Carbapenem Resistant Klebsiella pneumoniae and Klebsiella quasipneumoniae Isolated from Lebanon.黎巴嫩分离的耐碳青霉烯肺炎克雷伯菌和产酸克雷伯菌的分子特征。
Sci Rep. 2019 Jan 24;9(1):531. doi: 10.1038/s41598-018-36554-2.
7
Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents.了解细菌生物膜对抗菌剂的耐药机制。
Open Microbiol J. 2017 Apr 28;11:53-62. doi: 10.2174/1874285801711010053. eCollection 2017.
8
Toxins of Prokaryotic Toxin-Antitoxin Systems with Sequence-Specific Endoribonuclease Activity.具有序列特异性内切核糖核酸酶活性的原核毒素-抗毒素系统毒素
Toxins (Basel). 2017 Apr 14;9(4):140. doi: 10.3390/toxins9040140.
9
High Persister Mutants in Mycobacterium tuberculosis.结核分枝杆菌中的高持久性突变体
PLoS One. 2016 May 13;11(5):e0155127. doi: 10.1371/journal.pone.0155127. eCollection 2016.
10
Ranking of persister genes in the same Escherichia coli genetic background demonstrates varying importance of individual persister genes in tolerance to different antibiotics.在相同大肠杆菌遗传背景下对持留菌基因进行排名，结果表明各个持留菌基因在耐受不同抗生素方面的重要性各不相同。
Front Microbiol. 2015 Sep 30;6:1003. doi: 10.3389/fmicb.2015.01003. eCollection 2015.
本文引用的文献
1
Molecular basis of symbiosis between Rhizobium and legumes.根瘤菌与豆科植物共生的分子基础。
Nature. 1997 May 22;387(6631):394-401. doi: 10.1038/387394a0.
2
Plasmid pSC101 harbors a recombination site, psi, which is able to resolve plasmid multimers and to substitute for the analogous chromosomal Escherichia coli site dif.质粒pSC101含有一个重组位点psi，它能够拆分质粒多聚体并替代大肠杆菌染色体上类似的位点dif。
J Bacteriol. 1994 Jun;176(11):3188-95. doi: 10.1128/jb.176.11.3188-3195.1994.
3
Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis.Hip的自动调节，一种由于抑制肽聚糖或DNA合成而影响致死率的操纵子。
J Bacteriol. 1994 Jul;176(13):4081-91. doi: 10.1128/jb.176.13.4081-4091.1994.
4
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.流感嗜血杆菌Rd的全基因组随机测序与组装
Science. 1995 Jul 28;269(5223):496-512. doi: 10.1126/science.7542800.
5
hipA, a newly recognized gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis.hipA是大肠杆菌K-12中一个新发现的基因，它影响胞壁质合成受抑制后的持续频率。
J Bacteriol. 1983 Aug;155(2):768-75. doi: 10.1128/jb.155.2.768-775.1983.
6
Transposition derivatives of an Hfr strain of Escherichia coli K-12.大肠杆菌K-12 Hfr菌株的转座衍生物
Genetics. 1967 Jul;56(3):503-25. doi: 10.1093/genetics/56.3.503.
7
Antibiotic tolerance among clinical isolates of bacteria.临床分离细菌中的抗生素耐受性
Annu Rev Pharmacol Toxicol. 1985;25:349-80. doi: 10.1146/annurev.pa.25.040185.002025.
8
The terminus region of the Escherichia coli chromosome contains two separate loci that exhibit polar inhibition of replication.大肠杆菌染色体的末端区域包含两个独立的位点，它们表现出对复制的极性抑制。
Proc Natl Acad Sci U S A. 1987 Apr;84(7):1754-8. doi: 10.1073/pnas.84.7.1754.
9
Molecular cloning and expression of hipA, a gene of Escherichia coli K-12 that affects frequency of persistence after inhibition of murein synthesis.大肠杆菌K-12中hipA基因的分子克隆与表达，该基因影响细胞壁肽聚糖合成受抑制后的持续存在频率。
J Bacteriol. 1986 May;166(2):399-403. doi: 10.1128/jb.166.2.399-403.1986.
10
Mutants of Escherichia coli K-12 exhibiting reduced killing by both quinolone and beta-lactam antimicrobial agents.大肠杆菌K-12的突变体对喹诺酮类和β-内酰胺类抗菌剂的杀伤作用均降低。
Antimicrob Agents Chemother. 1990 Oct;34(10):1938-43. doi: 10.1128/AAC.34.10.1938.
Zotero 插件