对具有低水平氟喹诺酮耐药性的耐甲氧西林和甲氧西林敏感金黄色葡萄球菌突变体的检测。
Examination of methicillin-resistant and methicillin-susceptible Staphylococcus aureus mutants with low-level fluoroquinolone resistance.
作者信息
Sulavik M C, Barg N L
机构信息
Department of Medicine, Division of Infectious Diseases, University of Michigan Medical School, and Department of Veterans Affairs Medical Center, Ann Arbor, Michigan, USA.
出版信息
Antimicrob Agents Chemother. 1998 Dec;42(12):3317-9. doi: 10.1128/AAC.42.12.3317.
Abstract
For Staphylococcus aureus, stepwise mutations result in high-level quinolone resistance. Methicillin-resistant and -susceptible quinolone-resistant, first-step mutants generated in vitro were obtained and found to be no different than those recovered from murine abscesses. Approximately 10% of all first-step mutants were resistant to ethidium bromide, and selected strains had mutations that mapped to flqB. NorA-mediated resistance among first-step mutants may be more prevalent than previously reported.
摘要
对于金黄色葡萄球菌，逐步突变会导致高水平喹诺酮耐药性。在体外获得了耐甲氧西林和对喹诺酮敏感的第一步喹诺酮耐药突变体，发现它们与从鼠脓肿中分离出的突变体没有差异。所有第一步突变体中约10%对溴化乙锭耐药，所选菌株的突变定位于flqB。第一步突变体中NorA介导的耐药性可能比之前报道的更为普遍。
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本文引用的文献
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