耐氟喹诺酮且对甲氧西林敏感及耐药的金黄色葡萄球菌临床分离株中的拓扑异构酶突变
Topoisomerase mutations in fluoroquinolone-resistant and methicillin-susceptible and -resistant clinical isolates of Staphylococcus aureus.
作者信息
Kaatz G W, Seo S M
机构信息
Department of Internal Medicine, Department of Veteran's Affairs Medical Center and Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
出版信息
Antimicrob Agents Chemother. 1998 Jan;42(1):197-8. doi: 10.1128/AAC.42.1.197.
Abstract
The incidence of the various mutations in the genes encoding topoisomerase IV and DNA gyrase in fluoroquinolone-resistant clinical isolates of Staphylococcus aureus is not known. Using restriction fragment length polymorphism analysis and DNA sequencing, we found that in fluoroquinolone- and methicillin-resistant strains, mutations in grlA and gyrA are quite likely to be present together. For fluoroquinolone-resistant but methicillin-susceptible strains, mutations in grlA alone are more common.
摘要
耐氟喹诺酮金黄色葡萄球菌临床分离株中，编码拓扑异构酶IV和DNA促旋酶的基因发生各种突变的发生率尚不清楚。通过限制性片段长度多态性分析和DNA测序，我们发现，在耐氟喹诺酮和耐甲氧西林菌株中，grlA和gyrA突变很可能同时存在。对于耐氟喹诺酮但对甲氧西林敏感的菌株，单独的grlA突变更为常见。
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