Egan S, Wiener P, Kallifidas D, Wellington E M
Department of Biological Sciences, University of Warwick, Coventry, United Kingdom CV4 7AL.
Appl Environ Microbiol. 1998 Dec;64(12):5061-3. doi: 10.1128/AEM.64.12.5061-5063.1998.
Streptomyces strains isolated from soil were found to possess various numbers of genes from the streptomycin biosynthesis cluster. The strains missing genes from the cluster also lacked the ability to produce streptomycin. Two of the isolates which contain only part of the cluster are apparently recipients of a gene transfer event. The implications for the role of gene transfer in antibiotic evolution are discussed.
从土壤中分离出的链霉菌菌株被发现拥有来自链霉素生物合成簇的不同数量的基因。该簇中缺失基因的菌株也缺乏产生链霉素的能力。仅包含该簇部分基因的两个分离株显然是基因转移事件的受体。文中讨论了基因转移在抗生素进化中的作用。