Aaboe M, Pinholt E M, Schou S, Hjørting-Hansen E
Department of Oral and Maxillofacial Surgery, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Denmark.
Clin Oral Implants Res. 1998 Oct;9(5):313-20. doi: 10.1034/j.1600-0501.1998.090504.x.
The present study describes the use of a degradable and a non-degradable material for guided bone regeneration. Forty rabbits were divided into 5 groups. Bicortical defects 15 mm in diameter were prepared in rabbit calvaria. A titanium microplate was placed over the defect to prevent collapse of the membrane. The calvarial defects of 2 groups were covered by an outer expanded polytetrafluoroethylene (ePTFE) membrane respectively by a Polyglactin 910 membrane. Bicortical ePTFE membranes or Polyglactin 910 membranes were used in 2 other groups. The defects were not covered by membranes in the control group. Undecalcified sections were prepared for histologic evaluation after an observation period of 8 weeks. Complete bone healing of the defects was not observed in any of the specimens. The Polyglactin 910 material lacks physical strength, resulting in collapse of the membrane and brain tissue herniation into the defects. Subsequently, bone regeneration was impaired. The cellular reactions due to degradation of the material were minor and did not interfere with bone healing. Defects covered bicortically by ePTFE membranes revealed the largest amount of regenerated bone. The ePTFE membrane induced a severe cellular reaction, but no inhibition of bone regeneration was noted.
本研究描述了可降解和不可降解材料在引导骨再生中的应用。40只兔子被分为5组。在兔颅骨上制备直径为15毫米的双皮质缺损。在缺损上方放置一块钛微型板以防止膜塌陷。2组的颅骨缺损分别用外部膨体聚四氟乙烯（ePTFE）膜和聚乙交酯910膜覆盖。另外2组使用双皮质ePTFE膜或聚乙交酯910膜。对照组的缺损未用膜覆盖。在观察8周后制备未脱钙切片进行组织学评估。在任何标本中均未观察到缺损的完全骨愈合。聚乙交酯910材料缺乏物理强度，导致膜塌陷和脑组织疝入缺损。随后，骨再生受损。材料降解引起的细胞反应较小，且不干扰骨愈合。双皮质被ePTFE膜覆盖的缺损显示出再生骨量最大。ePTFE膜引起严重的细胞反应，但未观察到对骨再生有抑制作用。
