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聚丙交酯共聚物植入物和富血小板血浆对绵羊大型颅骨缺损内骨再生的影响。

Effects of Polylactide Copolymer Implants and Platelet-Rich Plasma on Bone Regeneration within a Large Calvarial Defect in Sheep.

机构信息

Department of Neurosurgery in Sosnowiec, Medical University of Silesia, Katowice, Poland.

Academy of Physical Education, Katowice, Poland.

出版信息

Biomed Res Int. 2018 May 13;2018:4120471. doi: 10.1155/2018/4120471. eCollection 2018.

DOI:10.1155/2018/4120471
PMID:29862268
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5971313/
Abstract

The aim of this study was to verify whether L-lactide/DL-lactide copolymer 80/20 (PLDLLA) and platelet-rich plasma (PRP) trigger bone formation within critical-sized calvarial defects in adult sheep ( = 6). Two craniectomies, each ca. 3 cm in diameter, were created in each animal. The first craniectomy was protected with an inner polylactide membrane, filled with PRP-polylactide granules, and covered with outer polylactide membrane. The second control craniectomy was left untreated. The animals were euthanized at 6, 7, 17, 19, 33, and 34 weeks after surgery, and the quality and the rate of reossification were assessed histomorphometrically and microtomographically. The study demonstrated that application of implants made of PLDLLA 80/20 combined with an osteopromotive substance (e.g., PRP) may promote bone healing in large calvarial defect in sheep. These promising proof-of-concept studies need to be verified in the future on a larger cohort of animals and over a longer period of time in order to draw definitive conclusions.

摘要

本研究旨在验证 L-丙交酯/DL-丙交酯共聚物 80/20（PLDLLA）和富血小板血浆（PRP）是否能在成年绵羊的临界尺寸颅骨缺损中引发骨形成（=6）。在每个动物中各创建了两个约 3cm 直径的颅骨切除术。第一个颅骨切除术用内聚乳酸膜保护，填充 PRP-聚乳酸颗粒，并覆盖外聚乳酸膜。第二个对照颅骨切除术则未处理。手术后 6、7、17、19、33 和 34 周时对动物进行安乐死，并通过组织形态计量学和 microtomography 评估骨再矿化的质量和速度。该研究表明，应用由 PLDLLA 80/20 与骨诱导物质（例如 PRP）制成的植入物可能促进绵羊大颅骨缺损中的骨愈合。这些有前途的概念验证研究需要在未来的更大动物队列和更长时间内进行验证，以得出明确的结论。

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