Brusco G, Izzi L, Corazza G R
Department of Internal Medicine, University of L'Aquila, Catania, Italy.
Ital J Gastroenterol Hepatol. 1998 Oct;30(5):496-7.
We have prospectively searched for IgA anti-transglutaminase antibodies by an enzyme-linked immunosorbent assay test in 20 untreated coeliacs and 21 patients with small bowel diseases other than coeliac disease consecutively referred to our Malabsorption Clinic. All the untreated coeliacs and one out of 21 disease controls turned out to be positive for the presence of these antibodies. The use of the enzyme-linked immunosorbent assay test for anti-transglutaminase antibodies could represent a new screening test for coeliac disease, in fact, this new enzyme-linked immunosorbent assay test has an absolute sensitivity and a satisfactory specificity and, in comparison to antiendomysial antibodies, is less expensive and avoids the ethical problems related to the use of monkey oesophagus.
我们通过酶联免疫吸附测定试验，对20名未经治疗的乳糜泻患者以及21名除乳糜泻外患有小肠疾病的患者进行了前瞻性研究，这些患者均连续转诊至我们的吸收不良诊所。结果发现，所有未经治疗的乳糜泻患者以及21名疾病对照中的1名，这些抗体检测呈阳性。使用酶联免疫吸附测定试验检测抗转谷氨酰胺酶抗体可能成为乳糜泻的一种新的筛查试验，事实上，这种新的酶联免疫吸附测定试验具有绝对的敏感性和令人满意的特异性，而且与抗肌内膜抗体相比，成本更低，还避免了与使用猴食管相关的伦理问题。
