Segerstrom S C, Solomon G F, Kemeny M E, Fahey J L
Department of Psychology, University of Kentucky, Lexington 40506-0044, USA.
J Behav Med. 1998 Oct;21(5):433-50. doi: 10.1023/a:1018732309353.
Worry is a cognitive activity in which potential problems are anticipated and enumerated in an attempt to control the future. Worry has been associated with dysregulation of the autonomic nervous system, which may extend to the immune system. The relationship between trait worry and immune parameters was investigated at three follow-up points after the Northridge earthquake in a sample of 47 hospital employees. Participants with scores above the median on a trait worry measure had fewer natural killer cells than participants with worry scores below the median and controls. This effect was not mediated by intrusive thoughts, avoidance, anxious mood, or health behavior. These results suggest that worry may have a detrimental effect on the regulation of natural killer cells during stress. This effect may be due to differences in autonomic responsiveness associated with worry.
担忧是一种认知活动，在此过程中，人们会预想潜在问题并逐一列举，试图掌控未来。担忧与自主神经系统失调有关，这种失调可能会延伸至免疫系统。在北岭地震后的三个随访点，对47名医院员工样本进行了特质性担忧与免疫参数之间关系的研究。在特质性担忧量表上得分高于中位数的参与者，其自然杀伤细胞数量少于担忧得分低于中位数的参与者及对照组。这种效应并非由侵入性思维、回避行为、焦虑情绪或健康行为介导。这些结果表明，担忧可能会在压力期间对自然杀伤细胞的调节产生不利影响。这种效应可能是由于与担忧相关的自主反应性差异所致。
