（1→3）-β-D-葡聚糖和内毒素调节对吸入性变应原的免疫反应。
(1-->3)-beta-D-glucan and endotoxin modulate immune response to inhaled allergen.
作者信息
Rylander R, Holt P G
机构信息
Department of Environmental Medicine, University of Gothenburg, Sweden.
出版信息
Mediators Inflamm. 1998;7(2):105-10. doi: 10.1080/09629359891252.
Abstract
Exposure to dust may involve co-exposure to agents which are allergens, together with those which are pro-inflammatory. To study the effects of such a co-exposure, the humoral and inflammatory responses were studied in guinea pigs inhaling the T-cell-dependent antigen ovalbumin (OVA) and the inflammatory agents (1 --> 3)-beta-D-glucan and lipopolysaccharide (LPS). The effects were evaluated as inflammatory cells in the lung and serum antibodies to OVA. LPS caused a stimulation of the OVA-induced antibody production which was abolished by simultaneous exposure to (1 --> 3)-beta-D-glucan. An increase of eosinophils after OVA exposure was decreased by co-exposure to (1 --> 3)-beta-D-glucan. The results demonstrate a complex interaction between adaptive and innate immune mechanisms in the lung, determined by exposure to common contaminants in airborne dust.
摘要
接触灰尘可能涉及同时接触过敏原以及促炎物质。为了研究这种共同接触的影响，在豚鼠吸入T细胞依赖性抗原卵清蛋白（OVA）以及炎症因子（1→3）-β-D-葡聚糖和脂多糖（LPS）的情况下，对其体液和炎症反应进行了研究。通过肺部的炎症细胞和针对OVA的血清抗体来评估这些影响。LPS会刺激OVA诱导的抗体产生，而同时接触（1→3）-β-D-葡聚糖可消除这种刺激。OVA暴露后嗜酸性粒细胞的增加在同时接触（1→3）-β-D-葡聚糖时会减少。结果表明，肺部适应性免疫和先天性免疫机制之间存在复杂的相互作用，这种相互作用由接触空气中灰尘中的常见污染物所决定。
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本文引用的文献
1
Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor.
J Exp Med. 1993 Jun 1;177(6):1773-7. doi: 10.1084/jem.177.6.1773.
2
Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages.
J Exp Med. 1993 Feb 1;177(2):397-407. doi: 10.1084/jem.177.2.397.
3
Pulmonary inflammation induced by repeated inhalations of beta(1,3)-D-glucan and endotoxin.
Int J Exp Pathol. 1994 Apr;75(2):85-90.
4
Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces.
J Exp Med. 1994 Apr 1;179(4):1331-6. doi: 10.1084/jem.179.4.1331.
5
Oxygen metabolites from lavage and interstitial lung cells after inhalation of endotoxin in guinea pigs.
Int Arch Allergy Immunol. 1994 May;104(1):42-7. doi: 10.1159/000236707.
6
Blood inflammatory response to inhaled endotoxin in normal subjects.
Clin Exp Allergy. 1995 Jan;25(1):73-9. doi: 10.1111/j.1365-2222.1995.tb01005.x.
7
Inflammation, immunoregulation, and inducible nitric oxide synthase.
J Leukoc Biol. 1993 Aug;54(2):171-8.
8
Adoptive transfer of "persistent' IgE responses in mice in the absence of secondary antigenic stimulation.
Int Arch Allergy Appl Immunol. 1981;66(4):357-64. doi: 10.1159/000232844.
9
Endotoxins and the lung: cellular reactions and risk for disease.
Prog Allergy. 1983;33:332-44.
10
Update on the immunomodulating activities of glucans.
Springer Semin Immunopathol. 1985;8(4):387-400. doi: 10.1007/BF01857392.
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