Hornum I, Transbol I
Acta Med Scand. 1976;200(5):341-9. doi: 10.1111/j.0954-6820.1976.tb08244.x.
Combined calcium balance and 47Ca turnover studies in sarcoidosis (4 patients) and vitamin D intoxication (1 patient) disclosed three different patterns of calcium metabolism. On patient with sarcoidosis had a normal metabolism of calcium, and two patients presented the usual pattern of intestinal hyperabsorption, hypercalcemia, and hypercalciuria. The fourth patient with sarcoidosis and the patient with vitamin D intoxication, both studied during spontaneous remissions, presented the third pattern. The main features here were hypercalcemia despite normal intestinal absorption of calcium, enlarged exchangeable calcium pool, accelerated accretion and resorption rates, hypercalciuria, and a distinctly negative calcium balance. This pattern of remission seems to represent a mobilization of extraosseous or metastatic calcifications, rather than a resorption of bone calcium.
对结节病患者(4例)和维生素D中毒患者(1例)进行的钙平衡与⁴⁷Ca周转率联合研究揭示了三种不同的钙代谢模式。1例结节病患者钙代谢正常,2例呈现肠道钙吸收增加、高钙血症和高钙尿症的常见模式。在自发缓解期进行研究的第4例结节病患者和维生素D中毒患者呈现出第三种模式。其主要特征是尽管肠道钙吸收正常但仍有高钙血症、可交换钙池增大、钙的沉积和再吸收率加快、高钙尿症以及明显的负钙平衡。这种缓解模式似乎代表了骨外或转移性钙化的动员,而非骨钙的再吸收。