Kimberlin D W, Whitley R J
Department of Pediatrics, The University of Alabama at Birmingham, USA.
J Neurovirol. 1998 Oct;4(5):474-85. doi: 10.3109/13550289809113492.
Discovered only 12 years ago, human herpesvirus-6 (HHV-6) has been associated with central nervous system (CNS) findings such as febrile seizures, encephalitis, meningitis, and possibly multiple sclerosis. These manifestations have been reported in both immunocompetent and immunocompromised individuals. The applications of such sophisticated laboratory tools as polymerase chain reaction, in situ hybridization, immunohistochemical staining, and representational difference analysis have expanded knowledge of the spectrum of CNS disease attributable to HHV-6 while delineating pathogenic mechanisms of both primary HHV-6 infection and reactivation from latency. This article reviews existing knowledge of the CNS manifestations of HHV-6, focusing on both clinical aspects of HHV-6 infection and its pathogenesis on neurologic diseases.
人类疱疹病毒6型（HHV-6）12年前才被发现，它与中枢神经系统（CNS）的一些表现有关，如热性惊厥、脑炎、脑膜炎，还可能与多发性硬化症有关。免疫功能正常和免疫功能低下的个体均有这些表现的报道。聚合酶链反应、原位杂交、免疫组织化学染色和代表性差异分析等精密实验室工具的应用，在明确原发性HHV-6感染和潜伏激活的致病机制的同时，也扩展了我们对HHV-6所致中枢神经系统疾病谱的认识。本文综述了HHV-6中枢神经系统表现的现有知识，重点关注HHV-6感染的临床方面及其对神经系统疾病的发病机制。
