双侧视神经病变与单侧强直性瞳孔伴急性人类疱疹病毒6型感染：一例报告
Bilateral optic neuropathy and unilateral tonic pupil associated with acute human herpesvirus 6 infection: a case report.
作者信息
Oberacher-Velten Isabel M, Jonas Jost B, Jünemann Anselm, Schmidt Barbara
机构信息
Department of Ophthalmology and University Eye Hospital, University of Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany.
出版信息
Graefes Arch Clin Exp Ophthalmol. 2005 Feb;243(2):175-7. doi: 10.1007/s00417-004-0986-8. Epub 2004 Sep 10.
BACKGROUND
Human herpesvirus 6 (HHV-6), a widespread virus and causative agent of exanthema subitum in children, has been associated with a number of neurologic disorders including cranial nerve palsies, seizures, encephalitis, meningitis, and multiple sclerosis.
PATIENT
A 31-year-old man presented with bilateral optic neuropathy, disc edema, and unilateral tonic pupil, which were found to be associated with acute HHV-6 infection. The patient had been suffering from juvenile diabetes for 5 years. One week after onset of intravenous antiviral therapy with foscarnet, disc edema subsided, and tonic pupil reaction was no longer detectable.
CONCLUSIONS
HHV-6 infection may play a role as a causative agent in patients with optic neuropathy and tonic pupil.
背景
人疱疹病毒6型（HHV-6）是一种广泛传播的病毒，是儿童急疹的病原体，与多种神经系统疾病有关，包括颅神经麻痹、癫痫、脑炎、脑膜炎和多发性硬化症。
患者
一名31岁男性出现双侧视神经病变、视盘水肿和单侧强直性瞳孔，发现与急性HHV-6感染有关。该患者患有青少年糖尿病5年。在用膦甲酸钠进行静脉抗病毒治疗开始一周后，视盘水肿消退，强直性瞳孔反应不再可检测到。
结论
HHV-6感染可能在视神经病变和强直性瞳孔患者中作为病原体起作用。
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