Ishikawa-Nishimura Mai, Kondo Makoto, Matsushima Yoshiaki, Habe Koji, Yamanaka Keiichi
Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Japan.
Case Rep Dermatol. 2021 Jan 25;13(1):18-22. doi: 10.1159/000511494. eCollection 2021 Jan-Apr.
We report a case of pruritic urticarial papules and plaques of pregnancy (PUPPP) starting with target lesions on both forearms at the end of second pregnancy. The patient's target lesions became generalized itchy edematous eczema lesions especially on her abdomen extended by pregnancy, which immediately disappeared postpartum. The mechanism PUPPP has not been elucidated so far; however, the typical target lesion was the initial phenotype in the current case. To approach the pathophysiology of PUPPP, we examined the cytokine profile in the patient's serum before and after delivery. The upregulated Th2 cytokine profile including IL-9 and IL-33, and the reaction against skin-resident bacteria and fungus might be involved in PUPPP.
我们报告一例妊娠性瘙痒性荨麻疹性丘疹和斑块（PUPPP）病例，该病例在第二次妊娠末期始于双侧前臂出现靶形损害。患者的靶形损害发展为泛发性瘙痒性水肿性湿疹损害，尤其是在因妊娠而扩展的腹部，产后这些损害立即消失。目前PUPPP的发病机制尚未阐明；然而，典型的靶形损害是本例的初始表型。为了探究PUPPP的病理生理学，我们检测了患者分娩前后血清中的细胞因子谱。包括IL-9和IL-33在内的Th2细胞因子谱上调，以及对皮肤常驻细菌和真菌的反应可能与PUPPP有关。
