von Noorden G K, Crawford M L
Invest Ophthalmol Vis Sci. 1978 Aug;17(8):762-8.
The effects of short-term unilateral form vision deprivation by suturing the lids in macaques were evaluated in terms of cortical neuronal electrophysiology and cell sizes in the lateral geniculate nucleus (LGN). The results show that cell shrinkage in the LGN is proportional to the duration of lid closure, with the parvocellular laminae being somewhat more sensitive than the magnocellular layers. Conversely, the electrophysiologically demonstrable shift of cortical dominance in favor of the nondeprived eye occurs after only 1 week of deprivation, with equal severity in short-term and long-term deprived monkeys, and precedes the appearance of histological abnormalities in the LGN. This increased cortical vs. geniculate sensitivity to visual deprivation is further demonstrated by the findings that (1) lid closure near the end of the second month of life does not affect the LGN cell size but causes the cortical electrophysiological deprivation effect and (2) the cortical eye dominance but not the size of the geniculate cells can be reversed in favor of the previously deprived eye by surgical closure of the formerly dominant eye.
通过缝合猕猴眼睑造成短期单侧形觉剥夺，从皮质神经元电生理学和外侧膝状体（LGN）细胞大小方面进行了评估。结果表明，LGN中的细胞萎缩与眼睑闭合持续时间成正比，小细胞层比大细胞层稍敏感。相反，电生理学上可证明的皮质优势偏向未剥夺眼的转变在剥夺仅1周后就会出现，短期和长期剥夺的猴子中严重程度相同，且先于LGN中组织学异常的出现。对视觉剥夺的皮质与膝状体敏感性增加进一步体现在以下发现中：（1）出生后第二个月末附近的眼睑闭合不影响LGN细胞大小，但会导致皮质电生理剥夺效应；（2）通过手术闭合先前占主导地位的眼睛，皮质眼优势而非膝状体细胞大小可偏向先前剥夺的眼睛而逆转。
