Crawford M L, von Noorden G K
Invest Ophthalmol Vis Sci. 1979 May;18(5):496-505.
Experimental esotropia was produced surgically in infant rhesus monkeys (Macaca mulatta) for brief periods of time. Electrophysiological studies of the visual cortex showed that esotropia of only 2 weeks duration in an infant monkey is sufficient to cause a marked shift of dominance in favor of the fixating eye and to virtually extinguish cortical neuronal responses from the esotropic eye. In the lateral geniculate nucleus cell (LGN), shrinkage of 6% to 8% occurred in the parvocellular layers connected with the esotropic eye, the magnocellular layers showing no changes. After the fixating eye had been sutured for 3 weeks, a complete reversal of the cortical physiology in favor of the esotropic eye occurred, whereas no recovery in cell size was observed in the LGN. Surgical realignment of an esotropic eye caused recovery of cortical neuronal responses from the formerly esotropic eye, but the number of binocularly responsive cells remained reduced.
通过手术在幼年恒河猴（猕猴）身上短时间诱发实验性内斜视。对视皮层的电生理研究表明，幼年猴子仅持续2周的内斜视就足以导致优势明显偏向注视眼，并几乎消除来自内斜眼的皮层神经元反应。在外侧膝状体细胞（LGN）中，与内斜眼相连的小细胞层出现了6%至8%的萎缩，大细胞层未发生变化。在注视眼被缝合3周后，皮层生理功能完全逆转，转而有利于内斜眼，而在LGN中未观察到细胞大小的恢复。手术矫正内斜眼可使原先内斜眼的皮层神经元反应恢复，但双眼反应性细胞的数量仍减少。
