Mewes H W, Heumann K, Kaps A, Mayer K, Pfeiffer F, Stocker S, Frishman D
GSF-Forschungszentrum für Umwelt und Gesundheit, Munich Information Center for Protein Sequences, am Max-Planck-Instut für Biochemie, Am Klopferspitz 18, D-82152 Martinsried, Germany.
Nucleic Acids Res. 1999 Jan 1;27(1):44-8. doi: 10.1093/nar/27.1.44.
The Munich Information Center for Protein Sequences (MIPS-GSF), Martinsried near Munich, Germany, develops and maintains genome oriented databases. It is commonplace that the amount of sequence data available increases rapidly, but not the capacity of qualified manual annotation at the sequence databases. Therefore, our strategy aims to cope with the data stream by the comprehensive application of analysis tools to sequences of complete genomes, the systematic classification of protein sequences and the active support of sequence analysis and functional genomics projects. This report describes the systematic and up-to-date analysis of genomes (PEDANT), a comprehensive database of the yeast genome (MYGD), a database reflecting the progress in sequencing the Arabidopsis thaliana genome (MATD), the database of assembled, annotated human EST clusters (MEST), and the collection of protein sequence data within the framework of the PIR-International Protein Sequence Database (described elsewhere in this volume). MIPS provides access through its WWW server (http://www.mips.biochem.mpg.de) to a spectrum of generic databases, including the above mentioned as well as a database of protein families (PROTFAM), the MITOP database, and the all-against-all FASTA database.
位于德国慕尼黑附近马丁斯里德的慕尼黑蛋白质序列信息中心（MIPS-GSF）开发并维护面向基因组的数据库。现有序列数据量迅速增加，但序列数据库中合格的人工注释能力却没有相应提高，这是很常见的情况。因此，我们的策略旨在通过将分析工具全面应用于完整基因组序列、对蛋白质序列进行系统分类以及积极支持序列分析和功能基因组学项目来应对数据流。本报告介绍了基因组的系统和最新分析（PEDANT）、酵母基因组综合数据库（MYGD）、反映拟南芥基因组测序进展的数据库（MATD）、组装注释的人类EST簇数据库（MEST）以及PIR国际蛋白质序列数据库框架内的蛋白质序列数据集合（本卷其他地方有描述）。MIPS通过其万维网服务器（http://www.mips.biochem.mpg.de）提供对一系列通用数据库的访问，包括上述数据库以及蛋白质家族数据库（PROTFAM）、线粒体数据库和全对全FASTA数据库。
