PEDB：前列腺表达数据库。
PEDB: the Prostate Expression Database.
作者信息
Hawkins V, Doll D, Bumgarner R, Smith T, Abajian C, Hood L, Nelson P S
机构信息
Department of Molecular Biotechnology and Department of Medicine, University of Washington, Seattle, WA 98195, USA.
出版信息
Nucleic Acids Res. 1999 Jan 1;27(1):204-8. doi: 10.1093/nar/27.1.204.
The Prostate Expression Database (PEDB) is a curated relational database and suite of analysis tools designed for the study of prostate gene expression in normal and disease states. Expressed Sequence Tags (ESTs) and full-length cDNA sequences derived from more than 40 human prostate cDNA libraries are maintained and represent a wide spectrum of normal and pathological conditions. Detailed library information including tissue source, library construction methods, sequence diversity and abundance are available in a library archive. Prostate ESTs are assembled into distinct species groups using the multiple alignment program CAP2 and are annotated with information from the GenBank, dbEST and Unigene public sequence databases. Annotated sequences in PEDB are searched using the BLAST algorithm. The differential expression of each EST species can be viewed across all libraries using a Virtual Expression Analysis Tool (VEAT), a graphical user interface written in Java for intra- and inter-library species comparisons. PEDB may be accessed via the World Wide Web at http://www.mbt.washington.edu/PEDB/
前列腺表达数据库（PEDB）是一个经过整理的关系型数据库以及一套分析工具，旨在研究正常和疾病状态下的前列腺基因表达。该数据库保存了来自40多个人类前列腺cDNA文库的表达序列标签（EST）和全长cDNA序列，代表了广泛的正常和病理状况。文库档案中提供了详细的文库信息，包括组织来源、文库构建方法、序列多样性和丰度。使用多重比对程序CAP2将前列腺EST组装成不同的物种组，并使用来自GenBank、dbEST和Unigene公共序列数据库的信息进行注释。使用BLAST算法在PEDB中搜索注释序列。每个EST物种的差异表达可以通过虚拟表达分析工具（VEAT）在所有文库中查看，VEAT是一个用Java编写的图形用户界面，用于库内和库间物种比较。可通过万维网访问PEDB，网址为http://www.mbt.washington.edu/PEDB/
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