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联合抗逆转录病毒治疗后人类免疫缺陷病毒特异性效应细胞毒性T淋巴细胞的衰变动力学

Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy.

作者信息

Ogg G S, Jin X, Bonhoeffer S, Moss P, Nowak M A, Monard S, Segal J P, Cao Y, Rowland-Jones S L, Hurley A, Markowitz M, Ho D D, McMichael A J, Nixon D F

机构信息

Institute of Molecular Medicine, Nuffield Department of Medicine, Oxford OX3 9DS, United Kingdom.

出版信息

J Virol. 1999 Jan;73(1):797-800. doi: 10.1128/JVI.73.1.797-800.1999.

DOI:10.1128/JVI.73.1.797-800.1999
PMID:9847391
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC103892/
Abstract

Little is known of the changes in human immunodeficiency virus type 1 (HIV-1)-specific effector cytotoxic T lymphocytes (CTL) after potent antiretroviral therapy. Using HLA/peptide tetrameric complexes, we show that after starting treatment, there are early rapid fluctuations in the HIV-1-specific CTL response which last 1 to 2 weeks. These fluctuations are followed by an exponential decay (median half-life, 45 days) of HIV-1-specific CTL which continues while viremia remains undetectable. These data have implications for the immunological control of drug-resistant virus.

摘要

对于高效抗逆转录病毒治疗后1型人类免疫缺陷病毒（HIV-1）特异性效应细胞毒性T淋巴细胞（CTL）的变化，人们了解甚少。利用HLA/肽四聚体复合物，我们发现开始治疗后，HIV-1特异性CTL反应会出现持续1至2周的早期快速波动。这些波动之后是HIV-1特异性CTL的指数衰减（中位半衰期为45天），在病毒血症仍检测不到时这种衰减仍在继续。这些数据对耐药病毒的免疫控制具有重要意义。

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本文引用的文献

1
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J Virol. 1999 Feb;73(2):1708-14. doi: 10.1128/JVI.73.2.1708-1714.1999.
2
Strong human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte activity in Sydney Blood Bank Cohort patients infected with nef-defective HIV type 1.悉尼血库队列中感染1型nef缺陷型人类免疫缺陷病毒（HIV）患者的强大HIV特异性细胞毒性T淋巴细胞活性
J Virol. 1999 Jan;73(1):436-43. doi: 10.1128/JVI.73.1.436-443.1999.
3
Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific.慢性HIV感染中CD8(+) T细胞的寡克隆扩增具有抗原特异性。
J Exp Med. 1998 Aug 17;188(4):785-90. doi: 10.1084/jem.188.4.785.
4
Toward HIV eradication or remission: the tasks ahead.迈向消除或缓解艾滋病毒：未来的任务。
Science. 1998 Jun 19;280(5371):1866-7. doi: 10.1126/science.280.5371.1866.
5
Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.HIV-1特异性细胞毒性T淋巴细胞的定量分析及病毒RNA的血浆载量
Science. 1998 Mar 27;279(5359):2103-6. doi: 10.1126/science.279.5359.2103.
6
Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.计数抗原特异性CD8 T细胞：对病毒感染期间旁观者激活的重新评估。
Immunity. 1998 Feb;8(2):177-87. doi: 10.1016/s1074-7613(00)80470-7.
7
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8
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10
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