一种干扰素诱导剂9-甲基链霉咪唑酮对小鼠白色念珠菌感染的影响。
Effect of an interferon inducer, 9-methylstreptimidone, on Candida albicans infection in mice.
作者信息
Umenai T, Suzuki F, Ishida N
出版信息
Antimicrob Agents Chemother. 1978 Jun;13(6):939-43. doi: 10.1128/AAC.13.6.939.
The protective effect of an interferon inducer with a low molecular weight, 9-methylstreptimidone (9-MS), against Candida albicans infection in mice was investigated. The antibiotic was effective only when given prophylactically. When administered in such a manner, the growth of C. albicans in the kidneys and brain was inhibited at the initial stage of infection. The growth of C. albicans was not inhibited by the antibiotic in vitro, and no antifungal effect was obtained in a preparation containing induced interferon. These results suggest that the antifungal action of 9-methylstreptimidone in mice might be manifested not by direct antifungal activity but rather by a host-mediated activity that excludes interferon-inducing capability.
研究了一种低分子量的干扰素诱导剂9-甲基链霉咪唑酮（9-MS）对小鼠白色念珠菌感染的保护作用。该抗生素仅在预防性给药时有效。以这种方式给药时，在感染初期，白色念珠菌在肾脏和大脑中的生长受到抑制。该抗生素在体外对白色念珠菌的生长没有抑制作用，并且在含有诱导干扰素的制剂中未获得抗真菌效果。这些结果表明，9-甲基链霉咪唑酮在小鼠中的抗真菌作用可能不是通过直接的抗真菌活性表现出来，而是通过一种排除干扰素诱导能力的宿主介导活性表现出来。
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