Marmion L C, Desser K B, Lilly R B, Stevens D A
Antimicrob Agents Chemother. 1976 Sep;10(3):447-9. doi: 10.1128/AAC.10.3.447.
Miconazole was administered intravenously in six consecutive patients with, active coccidioidal infection. Such treatment was associated with progressive anemia and thrombocytosis. The hematological abnormalities appeared to be dose related and potentially reversible. Bone marrow studies demonstrated erythroid hypoplasia and increased or active platelet production in three subjects. No hemorrhagic or thrombotic episodes were identified. It is suggested that careful hematological monitoring be performed in subjects undergoing systemic miconazole therapy.
对6例活动性球孢子菌感染患者连续静脉注射咪康唑。这种治疗与进行性贫血和血小板增多有关。血液学异常似乎与剂量相关且可能可逆。骨髓研究显示，3例患者有红细胞生成减少以及血小板生成增加或活跃。未发现出血或血栓形成事件。建议对接受全身性咪康唑治疗的患者进行仔细的血液学监测。
