病毒唑对慢性乙肝表面抗原血清阳性黑猩猩的抗病毒作用。
Antiviral effects of virazole in chronic hepatitis B surface antigen-seropositive chimpanzees.
作者信息
Denes A E, Ebert J W, Berquist K R, Murphy B L, Maynard J E
出版信息
Antimicrob Agents Chemother. 1976 Sep;10(3):571-2. doi: 10.1128/AAC.10.3.571.
Abstract
Virazole (Ribavirin, ICN 1229), a broad-spectrum, antiviral chemotherapeutic agent was used to treat two adult chronically hepatitis B surface antigen (HB(s) Ag)-seropositive chimpanzees. No significant change in serum hepatitis B surface antigen was noted and no adverse reactions were observed. The role of viral replication in the chronic carrier state of hepatitis B is discussed.
摘要
病毒唑（利巴韦林，ICN 1229），一种广谱抗病毒化疗药物，被用于治疗两只成年慢性乙肝表面抗原（HB(s)Ag）血清阳性的黑猩猩。未观察到血清乙肝表面抗原出现显著变化，也未观察到不良反应。文中讨论了病毒复制在乙肝慢性携带状态中的作用。
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Duality of hepatitis B antigen and its antibody. I. Immunofluorescence studies.乙肝抗原与其抗体的双重性。I. 免疫荧光研究。
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Science. 1972 Aug 25;177(4050):705-6. doi: 10.1126/science.177.4050.705.
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Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent.新型广谱抗病毒药物1-β-D-呋喃核糖基-1,2,4-三唑-3-甲酰胺（病毒唑）的作用机制
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