Müller H W, Stoll G
Department of Neurology, Heinrich-Heine University, Düsseldorf, Germany.
Curr Opin Neurol. 1998 Oct;11(5):557-62. doi: 10.1097/00019052-199810000-00019.
Recent observations have provided new insight into neuronal responses to axotomy, signalling of the Schwann cell switch from 'operating' to 'proliferation' mode and temporal molecular changes in the responsiveness of Schwann cells to neuronal signals, as well as into the role of macrophages in Wallerian degeneration, nerve repair and neuropathic pain. Furthermore, promising therapeutic interventions have been developed to promote axon regeneration and to attenuate axotomy-induced neuronal cell death by means of pharmacological treatment or application of neurotrophic proteins using various strategies and routes of delivery.
最近的观察为神经元对轴突切断的反应、雪旺细胞从“运作”模式转变为“增殖”模式的信号传导、雪旺细胞对神经元信号反应性的时间性分子变化，以及巨噬细胞在沃勒变性、神经修复和神经性疼痛中的作用提供了新的见解。此外，已经开发出了有前景的治疗干预措施，通过药理学治疗或使用各种策略和递送途径应用神经营养蛋白来促进轴突再生并减轻轴突切断诱导的神经元细胞死亡。
