九种头孢菌素对肠杆菌科细菌和非发酵革兰氏阴性杆菌的抗菌活性比较。
Comparison of the antibacterial activity of nine cephalosporins against Enterobacteriaceae and nonfermentative gram-negative bacilli.
作者信息
Verbist L
出版信息
Antimicrob Agents Chemother. 1976 Oct;10(4):657-63. doi: 10.1128/AAC.10.4.657.
Abstract
The in vitro antibacterial activity of nine cephalosporins (cephalothin, cephaloridine, cephalexin, cefazolin, cefamandole, cefuroxime, cefatrizine, cefoxitin, and cefazaflur) was determined against 344 strains of Enterobacteriaceae and 99 nonfermentative gram-negative bacilli. Cefamandole, cefazaflur, and cefuroxime were the most active cephalosporins against the Enterobacteriaceae (with the exception of Serratia marcescens). However, cefoxitin was the only cephalosporin that inhibited all 30 S. marcescens strains in a concentration of 16 mug/ml and was by far the most active compound against selected cephalothin-resistant strains of Escherichia coli, Klebsiella, and Proteus mirabilis. Acinetobacter spp. were inhibited best by cefuroxime, but none of the cephalosporins had appreciable activity against the Pseudomonas spp.
摘要
测定了九种头孢菌素（头孢噻吩、头孢噻啶、头孢氨苄、头孢唑林、头孢孟多、头孢呋辛、头孢曲嗪、头孢西丁和头孢扎氟）对344株肠杆菌科细菌和99株非发酵革兰氏阴性杆菌的体外抗菌活性。头孢孟多、头孢扎氟和头孢呋辛是对肠杆菌科细菌（除粘质沙雷氏菌外）活性最强的头孢菌素。然而，头孢西丁是唯一一种在浓度为16μg/ml时能抑制所有30株粘质沙雷氏菌的头孢菌素，并且是迄今为止对所选头孢噻吩耐药的大肠杆菌、克雷伯菌和奇异变形杆菌菌株活性最强的化合物。不动杆菌属对头孢呋辛抑制效果最佳，但没有一种头孢菌素对假单胞菌属有明显活性。
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