Donchenko G V, Kholodova Iu D, Kuz'menko I V, Klimenko E P
A.V. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv.
Ukr Biokhim Zh (1978). 1998 Mar-Apr;70(2):37-45.
The effect of alpha-tocopherol and its derivatives on viability and growth of attached cells culture: human epithelioid carcinoma of cervix HeLa-S3K and human cervical carcinoma cell line C-4-1 according to protein content and level of alkaline phosphatase, as well to unattached cells: human acute leukemia cell cultures CEM-C-1 and CEM-C-7 according to the amount of viable cells in suspension has been studied. It has been shown that alpha-tocopherol acetate and tocopherol maintain the viability of cells, while the derivatives of tocopherol with shorted side chain considerably inhibit growth of researched cultures, alpha-tocopherol with lacking side chain being most active among them.
根据蛋白质含量和碱性磷酸酶水平，研究了α-生育酚及其衍生物对贴壁细胞培养物（人宫颈上皮样癌HeLa-S3K和人宫颈癌细胞系C-4-1）活力和生长的影响，以及对悬浮细胞（人急性白血病细胞培养物CEM-C-1和CEM-C-7）根据悬浮液中活细胞数量的影响。结果表明，α-生育酚乙酸酯和生育酚可维持细胞活力，而侧链较短的生育酚衍生物则显著抑制所研究培养物的生长，其中侧链缺失的α-生育酚最为活跃。
