Glebova L Iu
Ukrainian Medical Stomatological Academy, Poltava.
Ukr Biokhim Zh (1978). 1998 May-Jun;70(3):91-5.
The experimental study carried out with white rats Wistar trend, which were introduced of sodium nitrate at a rate of 9.6 g/kg of their mass. It follows to the development of considerable activation of lipid peroxidation and depression of antioxidant system in liver. The obtained results permit supposing the significant role of nitric oxide (NO) in liver as a factor resulting in accumulation of peroxidation products. The research has stated that the use hyperbaric oxygenation (HBO) prevents considerable activation of lipid peroxidation and the decrease of antioxidant enzyme (catalase and superoxide dismutase) activity. The results permit supposing that the effect HBO is connected with the decrease of the rate of reduction of nitrate-ions to NO.
对Wistar品系的白色大鼠进行了实验研究，以9.6克/千克体重的剂量给它们注射硝酸钠。结果发现，这导致肝脏中脂质过氧化反应显著激活，抗氧化系统受到抑制。所得结果表明，一氧化氮（NO）在肝脏中作为导致过氧化产物积累的一个因素起着重要作用。研究表明，使用高压氧疗法（HBO）可防止脂质过氧化反应的显著激活以及抗氧化酶（过氧化氢酶和超氧化物歧化酶）活性的降低。这些结果表明，HBO的作用与硝酸根离子还原为NO的速率降低有关。
