Hlebova L Iu
Medical Stomatological Academy, Ministry of Public Health of the Ukraine, Poltava.
Fiziol Zh (1994). 1998;44(1-2):24-9.
The experimental study carried out on white rats, which was introduced of sodium nitrate at a dose of 9,6 g/kg of their mass. It is followed by the development of considerable disturbances of energy metabolism in liver. It has been shown the depression and the uncoupling of oxidation and phosphorylation, decrease of energy quotient in hepatic tissues. The results obtained permit supposing the significant role of nitric oxide (NO) in liver as a factor resulting in decrease of energy potential. The research has stated that the use of hyperbaric oxygenation (HBO) prevents difficult disturbances of energy metabolism in liver of white rats. The results permit supposing that the effect HBO is connected with the decrease of the speed of reduction of nitrate-ions to more toxic products of their biotransformation.
对体重为9.6克/千克的白鼠进行了实验研究，给它们注射了硝酸钠。随后肝脏中能量代谢出现了严重紊乱。结果表明氧化磷酸化过程受到抑制和解偶联，肝组织中的能量商降低。所得结果表明一氧化氮（NO）在肝脏中作为导致能量潜力下降的一个因素起着重要作用。研究表明，使用高压氧疗法（HBO）可预防白鼠肝脏能量代谢的严重紊乱。这些结果表明，HBO的作用可能与硝酸根离子还原为其生物转化的毒性更大的产物的速度降低有关。
