Nayler S J, Taylor L, Cooper K
Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa.
Mol Pathol. 1998 Jun;51(3):168-70. doi: 10.1136/mp.51.3.168.
Follicular dendritic cell tumours are rare malignancies derived from the follicular dendritic cells of lymphoid follicles. These tumours have been associated with Epstein-Barr virus infections and with the hyaline vascular subtype of Castleman's disease. Because many examples of Castleman's disease have been associated with Kaposi's sarcoma associated herpes virus (HHV-8), this study uses polymerase chain reaction technology to examine five cases of follicular dendritic cell tumours for HHV-8. One of these cases had previously been documented to arise from pre-existing Castleman's disease. HHV-8 DNA was not detected in any of the follicular dendritic cell tumours examined, or in the original case of Castleman's disease. These findings suggest that HHV-8 plays no role in the aetiology of follicular dendritic cell tumours and the cause of this tumour remains obscure.
滤泡性树突状细胞瘤是源自淋巴滤泡的滤泡性树突状细胞的罕见恶性肿瘤。这些肿瘤与爱泼斯坦-巴尔病毒感染以及卡斯尔曼病的透明血管亚型有关。由于许多卡斯尔曼病病例都与卡波西肉瘤相关疱疹病毒（HHV-8）有关，本研究使用聚合酶链反应技术检测5例滤泡性树突状细胞瘤中的HHV-8。其中1例先前已记录为由先前存在的卡斯尔曼病发展而来。在所检查的任何滤泡性树突状细胞瘤中，或在原始卡斯尔曼病病例中均未检测到HHV-8 DNA。这些发现表明HHV-8在滤泡性树突状细胞瘤的病因中不起作用，该肿瘤的病因仍然不明。
