Morinville A, Maysinger D, Shaver A
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
Trends Pharmacol Sci. 1998 Nov;19(11):452-60. doi: 10.1016/s0165-6147(98)01257-7.
Vanadium compounds exert a variety of biological responses, the most notable being their effects as insulin mimetics. More recently, they have been used as pharmacological tools to investigate signalling pathways. Some peroxovanadium compounds act as powerful protein tyrosine phosphatase inhibitors, modulating both the extent and duration of phosphotyrosine signals at the level of the transmembrane growth factor receptors and targets in the cytoplasm and nucleus. A brief history of vanadium compounds, selected chemical properties of vanadium compounds and the ability of peroxovanadium complexes to modulate the activities of protein tyrosine phosphatases and tyrosine kinases are presented in this review by Anne Morinville, Dusica Maysinger and Alan Shaver. From the range of biological activities of these compounds, this review focuses on cytotoxic effects and possible roles of mitogen-activated protein kinases in mediating the effects exerted by vanadium compounds.
钒化合物会引发多种生物学反应，其中最显著的是它们作为胰岛素模拟物的作用。最近，它们被用作研究信号通路的药理学工具。一些过氧钒化合物可作为强大的蛋白质酪氨酸磷酸酶抑制剂，在跨膜生长因子受体以及细胞质和细胞核中的靶点水平上调节磷酸酪氨酸信号的程度和持续时间。安妮·莫林维尔、杜西卡·迈辛格和艾伦·谢弗在这篇综述中介绍了钒化合物的简史、钒化合物的选定化学性质以及过氧钒配合物调节蛋白质酪氨酸磷酸酶和酪氨酸激酶活性的能力。基于这些化合物的一系列生物学活性，本综述重点关注细胞毒性作用以及丝裂原活化蛋白激酶在介导钒化合物所产生效应中的可能作用。
